With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.
General procedure: 3-Chloroperbenzoic acid (2.5 mmol) was added to the stirredsolution of compound 4a or 4b (1.0 mmol) in dichloromethane(50 mL) in portions over a 20-30 min period. The mixture washeated to reflux for about 5 h and monitored by TLC. Aftercompletion, the mixture was cooled to room temperature and sodiumhydrogen sulfite (20 mL) was added. The solution was stirredfor 15 min and extracted with dichloromethane. The organic phasewas washed with aqueous sodium bicarbonate (2 x 30 mL). Theorganic phase was separated, washed with brine and dried withsodium sulfate, filtered, and the solvents were removed underreduced pressure to give the sulfone compound 5a or 5b., 1423-61-6
1423-61-6 7-Bromobenzo[b]thiophene 12045538, abenzothiophene compound, is more and more widely used in various fields.
Reference：
Article; Zhang, Wenda; Ma, Ting; Li, Shanshan; Yang, Yanwei; Guo, Jianpeng; Yu, Wenying; Kong, Lingyi; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 538 – 550;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem