Extracurricular laboratory:new discovery of 130-03-0

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Chemistry is traditionally divided into organic and inorganic chemistry. Safety of Benzo[b]thiophen-3(2H)-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 130-03-0

An organocatalytic asymmetric formal aza-[3+3]cycloaddition of readily available N-Tosyl-3-aminobenzofuran with alpha,beta-unsaturated aldehydes was developed for the first time. This method enables the facile synthesis of biologically active and synthetically challenging polysubstituted fused benzofuran derivatives bearing two stereocenters in high yields with excellent diastereo-, and enantioselectivity (up to >20 : 1 dr, and >99% ee). (Figure presented.).

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Final Thoughts on Chemistry for 6287-82-7

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Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring.category: benzothiophene, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6287-82-7, Name is 2,3-Dibromobenzo[b]thiophene, molecular formula is C8H4Br2S

Deprotonation of benzothiophene-derived alkynyl imine 11 with lithium diisopropylamide (LDA) and subsequent transmetalation with ZnCl2 etherate furnished azepine 12 upon aqueous workup. Similarly, alkynyl benzaldimine la gave a mixture of benzazepine 13 and naphthylamine 14. Allylic benzonitriles 15a,b reacted to produce naphthylamine 16 upon deprotonation with LDA at room temperature. In an analogous manner, imino benzonitrile 17 may be converted into 4-amino isoquinoline 18 by means of an intramolecular nucleophilic attack on the nitrile function upon treatment with LDA. The allylic benzonitriles 19a,b were prepared by LDA treatment of alkynyl imine 11. They were further converted to amino dibenzothiophene 20 by LDA deprotonation and aqueous workup. These various transformations represent the key steps of a multistep reaction cascade, which was previously postulated on the basis of quantum chemical calculations. Thus, all features of this complex rearrangement mechanism could now be confirmed experimentally. DFT calculations support the lower reactivity of zinc species in the ring-opening step compared to the lithium intermediates. All new compounds were completely characterized by spectroscopic data, including X-ray diffraction studies for the key compounds 12, 19a, and 20.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

A new application about C8H4Br2S

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Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring.name: 2,3-Dibromobenzo[b]thiophene, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6287-82-7, Name is 2,3-Dibromobenzo[b]thiophene, molecular formula is C8H4Br2S

This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of the compounds of formula I as thrombin inhibitors.

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Benzothiophene – Wikipedia,
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More research is needed about C16H14O2S

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Synthetic Route of 63675-74-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.63675-74-1, Name is 6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophene, molecular formula is C16H14O2S. In a Patent,once mentioned of 63675-74-1

This invention provides methods which are useful for the inhibition of the various medical conditions associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia utilizing compounds of formula I: STR1

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

The Absolute Best Science Experiment for C9H6BrClS

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The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. Computed Properties of C9H6BrClS, In an article, mentioned the application of 1198-51-2, Name is 3-(Bromomethyl)-5-chlorobenzo[b]thiophene, molecular formula is C9H6BrClS

A compound compound having the structure: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein A, A? and A? are independently O, C?O, C?R? or N?R?, where R? and R? may independently be H, amino, ?NR7COR6, COR6, ?CONR7R8, C1-C6 alkyl, or hydroxy(C1-C6 alkyl), and R? may be present or absent, and is present where the rules of valency permit, and where not more than one of A, A? and A? is O or C?O; R0 and R are independently H, Br, Cl, F, or C1-C6 alkyl; R1 is H, C1-C6 alkyl, or hydroxy(C1-C6 alkyl); R2 is selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, hydroxy(C1-C6 alkyl), phenyl(C1-C6 alkyl), formyl, heteroaryl, heterocyclic, ?COR6, ?OCOR6, ?COOR6, ?NR7COR6, ?CONR7R8, and ?(CH2)n?W, where W is cyano, hydroxy, C3-C8 cycloalkyl, ?SO2NR7R8, and ?SO2?R9, where R9 is C1-C6 alkyl, C3-C8 cycloalkyl, heteroaryl, or heterocyclic; wherein each of said alkyl, cycloalkyl, heterocyclic, or heteroaryl may be unsubstituted or substituted by halo, cyano, hydroxy, or C1-C6 alkyl; X is C?R3 or N, where R3 may be H or C1-C6 alkyl; R4 and R5 are independently H, amino, C1-C6 alkyl, or hydroxy(C1-C6 alkyl); R6, R7 and R8 are each independently H, C1-C6 alkyl, C1-C4 alkoxy(C1-C6 alkyl), or C3-C8 cycloalkyl, said C1-C6 alkyl is optionally substituted by halo, CN or hydroxy; or, R7 and R8 together with the atom bonded thereto form a 5- or 6-membered ring, said ring being optionally substituted by halo, hydroxy, CN, or C1-C6 alkyl; and, n is 0, 1, 2 or 3. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Final Thoughts on Chemistry for 1034305-23-1

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Electric Literature of 1034305-23-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1034305-23-1, Name is (2S,3R,4S,5S,6R)-2-(3-(Benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol, molecular formula is C22H23FO6S. In a Patent,once mentioned of 1034305-23-1

The present invention provides a method for producing a C-glycoside derivative, which can produce the C-glycoside derivative at a high yield and at a low cost, which conforms to environmental protection, and which is applicable industrially. The C-glycoside derivative is useful for treating and preventing diabetes such as insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes) and the like and various diabetes-related diseases including insulin-resistant diseases and obesity.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Simple exploration of C8H5BrS

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Electric Literature of 4923-87-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4923-87-9, Name is 5-Bromobenzothiophene, molecular formula is C8H5BrS. In a Article,once mentioned of 4923-87-9

Rh COT in the act: A Ni0-catalyzed [2+2+2+2] cycloaddition provides a high-yielding, scalable synthesis of the ligand dinaphtho[a,e] cyclooctatetraene (dnCOT). dnCOT complexation with RhI gives [Rh(dnCOT)(MeCN)2]SbF6 (see scheme), an excellent catalyst for [5+2] cycloadditions of vinylcyclopropanes and pi-systems with impressive functional group compatibility. Copyright

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Awesome Chemistry Experiments For C13H15NO2S

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Related Products of 89673-36-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 89673-36-9, Name is tert-Butyl benzo[b]thiophen-2-ylcarbamate,introducing its new discovery.

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Discovery of C8H4Br2S

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6287-82-7, Name is 2,3-Dibromobenzo[b]thiophene, belongs to benzothiophene compound, is a common compound. name: 2,3-Dibromobenzo[b]thiopheneIn an article, once mentioned the new application about 6287-82-7.

Photochromic terarylene derivative 4 which has a sulfone group at the upper benzothiophene ring is readily synthesized using Suzuki coupling reaction. It exhibits good photochromic properties. Interestingly, the closed form of the compound 4 shows a good photostability as well as a thermal stability compared with its reduced analog 3, that provides a method to enhance the photostability of versatile photochromic terarylenes under UV.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Archives for Chemistry Experiments of C9H5ClO2S

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Reference of 90407-16-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.90407-16-2, Name is 7-Chloro-1-benzothiophene-2-carboxylic acid, molecular formula is C9H5ClO2S. In a Patent,once mentioned of 90407-16-2

The disclosure provides compounds of formula I including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders. [INSERT CHEMICAL STRUCTURE HERE] I

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem