22913-24-2, Name is Methyl benzo[b]thiophene-2-carboxylate, belongs to benzothiophene compound, is a common compound. Formula: C10H8O2SIn an article, once mentioned the new application about 22913-24-2.
4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na +/H+ exchanger isoform-1 (NHE-1) inhibitors
A series of 4-substituted (benzo[b]thiophene-2-carbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardioprotective efficacy both in vitro and in vivo. Several analogs exhibited a strong inhibition on NHE-1, and which was generally well correlated with their cardioprotective efficacy. Especially the 4-nitro 20 and cyano 50 compounds excellently improved the cardiac function and reduced infarct size against ischemia/reperfusion injury.
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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem