Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. category: benzothiophene, C8H5BrS. A document type is Article, introducing its new discovery., category: benzothiophene
A new,: Substituted palladacycle for ppm level Pd-catalyzed Suzuki-Miyaura cross couplings in water
A newly engineered palladacycle that contains substituents on the biphenyl rings along with the ligand HandaPhos is especially well-matched to an aqueous micellar medium, enabling valued Suzuki-Miyaura couplings to be run not only in water under mild conditions, but at 300 ppm of Pd catalyst. This general methodology has been applied to several targets in the pharmaceutical area. Multiple recyclings of the aqueous reaction mixture involving both the same as well as different coupling partners is demonstrated. Low temperature microscopy (cryo-TEM) indicates the nature and size of the particles acting as nanoreactors. Importantly, given the low loadings of Pd invested per reaction, ICP-MS analyses of residual palladium in the products shows levels to be expected that are well within FDA allowable limits.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 5394-13-8, help many people in the next few years.category: benzothiophene
Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem