Month: April 2021

Synthetic Route of 22913-24-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 22913-24-2, Name is Methyl benzo[b]thiophene-2-carboxylate, molecular formula is C10H8O2S. In a Article，once mentioned of 22913-24-2

Benzo[b]thiophene-2-carboxamide derivatives as potent urotensin-II receptor antagonists

Members of a series of benzo[b]thiophene-2-carboxamide derivatives, possessing an N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)piperidin-4-yl) group, were synthesized and evaluated as urotensin-II receptor antagonists. The results show that these substances have potent UT binding affinities. Observations made in a systematic SAR investigation of the effects of a variety of substituents (R1and R2) at the 5- and 6-positions in the benzo[b]thiophene-2-carboxamide moiety on UT binding affinities led to identification of the 5-cyano analog 7f as a highly potent UT antagonist with an IC50value of 25 nM. Despite having a good metabolic stability, 7f is a potent inhibitor of CYP isozyme and displays an unsuitable PK profile.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 22913-24-2. In my other articles, you can also check out more blogs about 22913-24-2

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Synthetic Route of 63675-74-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.63675-74-1, Name is 6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophene, molecular formula is C16H14O2S. In a Patent，once mentioned of 63675-74-1

Process for preparing benzoic acids

An improved process for the preparation of 4[(2-piperidin-1-yl)ethoxy]benzoic acid derivatives, comprising reacting a haloalkyl amine of formula (III) with a compound of formula (IV) in the presence of a hydrated inorganic base in an appropriate solvent.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Reference of 360575-29-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.360575-29-7, Name is Methyl 4-bromobenzo[b]thiophene-2-carboxylate, molecular formula is C10H7BrO2S. In a Article，once mentioned of 360575-29-7

Tautomerism of N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide ? A new selective, highly potent and reversible MAO-B inhibitor

The tautomeric properties of an N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide (NTZ-1006, 2) derivative, developed as highly potent, reversible and selective MAO-B inhibitor useful for the treatment of Parkinson’s disease (PD) and other neurological disorders, have been studied both experimentally and theoretically. The theoretical data (M06?2X, B3LYP and MP2-4 quantum chemical calculations) have shown that due to aromaticity reasons the 1H tautomer strongly dominates over the 2H form. There are no substantial spectral changes by changing the solvent and the concentration, which leads to a conclusion that compound 2 exists in solution as 1H tautomer and its tautomerism is not influenced by the solvents and the concentration. The results are in line with the understanding for the tautomerism of 1H-indazole and shows that substitution at the C5 position in the indazole unit does not influence the tautomeric state. The isolated crystal structure of 2 is in an excellent agreement with the computation in respect of the most stable tautomer. Combined single X-ray/molecular modeling studies including HYdrogen-DEsolvation (HYDE) analysis provided not only insights into the enzyme?inhibitor interaction within the binding site of the human MAO-B isoform, but also a valuable information regarding the most stable 1H-indazole tautomeric form of NTZ-1006 that contributes to its high potency against hMAO-B enzyme (IC50 0.586 nm) and selectivity (>17000-fold) over the hMAO-A isoenzyme.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 360575-29-7

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate. SDS of cas: 130-03-0, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 130-03-0, Name is Benzo[b]thiophen-3(2H)-one, molecular formula is C8H6OS

Polycyclicpolythia compounds: Benzothiophen-3-one as potential synthon for the synthesis of 3,4-dihydro-2H,5H-thiopyrano<2',3':4,5>thiopyrano<3,2-b>benzothiophen-4-one – Part II

The total synthesis of 3,4-dihydro-2H,5H-thiopyrano<2',3':4,5>thiopyrano<3,2-b>benzothiophen-4-one (9) from benzothiophen-3-one (4) has been described.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. SDS of cas: 130-03-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 130-03-0, in my other articles.

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. Formula: C8H4Br2S, C8H4Br2S. A document type is Article, introducing its new discovery., Formula: C8H4Br2S

One-pot synthesis and property study on thieno[3,2-: B] furan compounds

Based on the regioselective intermolecular Suzuki coupling and subsequent intramolecular Ullmann C-O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-b]benzofurans (BTBFs) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh3)4 and 2 mol% copper(i) thiophene-2-carboxylate (CuTc) as the catalysts, K3PO4·3H2O as the base and tert-butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 6287-82-7, help many people in the next few years.Formula: C8H4Br2S

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C8H6OS, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 19301-35-0

Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors

A series of 3-heteroaryloxy-4-phenyl-2-(5H)-furanones were prepared and evaluated for their potency and selectivity as COX-2 inhibitors. This led to the identification of L-778,736 as a potent, orally active and selective inhibitor of the COX-2 enzyme.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Application of 19301-35-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 19301-35-0, Benzo[b]thiophen-5-ol, introducing its new discovery.

Addition Reactions of Benzothiophen. Part 4. Reactions of Some Acetoxy- and Hydroxy-benzothiophens with Benzene or Toluene

Heating acetoxybenzothiophens with AlCl3-benzene can give the normal Fries-rearranged products (for the 4-OAc and 7-OAc isomers); these sometimes react further to give their 2,3-dihydro- (for 4-OAc and 7-OAc) or 2-phenyl derivatives (for 6-OAc).Alternatively, benzene can add across the 2,3-double bond of the acetoxy-compound, to give the 2- (for 6-OAc) or 3-phenyl-2,3-dihydrobenzothiophens (for 7-Oac).With AlCl3 in dichloromethane, 6-acetoxybenzothiophen undergoes intermolecular transfer of an acetyl group to give a mixture of 6-acetoxy-2- and 3-acetylbenzothiophens and 6-hydroxybenzothiophen.With AlCl3 in benzene at room temperature, 4-acetoxybenzothiophen gives a rearranged product, 4,5-dihydro-2,4-diphenylbenzothiophen-7(6H)-one (3a) (17percent).In the presence of AlCl3 for 0.5 h, 4-, 5-, 6-, and 7-hydroxybenzothiophens undergo addition of benzene or toluene, to give the appropriate 2-aryl-2,3-dihydrohydroxybenzothiophens (1).Yields are high for the 4- and 6-hydroxy-isomers (80-85percent), but lower for the 5- (55percent) and 7-isomers (10percent).In each of these reactions the starting hydroxybenzothiophen is partly converted into its 2,3-dihydro-derivative. 5- and 7-Hydroxybenzothiophen also each give the same 4,5-dihydro-2,4-diarylbenzothiophen-7(6H)-one (3) (25percent) in this reaction.When the reaction period with benzene or toluene is extended to 5 days, the amount of solvent addition product (1) decreases, but all four hydroxy-isomers now give the same rearranged product (3).The mechanism of this unusual rearrangement is discussed in terms of a spiro-intermediate.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 19301-35-0. In my other articles, you can also check out more blogs about 19301-35-0

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem