Reference of 1196-19-6, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 1196-19-6, 3-(Bromomethyl)benzo[b]thiophene, introducing its new discovery.
Synthetic Utility of Arylmethylsulfones: Annulative pi-Extension of Aromatics and Hetero-aromatics Involving Pd(0)-Catalyzed Heck Coupling Reactions
A straightforward and general method for the synthesis of annulated thiophene, dibenzothiophene, and carbazoles analogues has been achieved involving alkylation of 2-bromo-1-(phenylsulfonylmethyl)arene/heteroarene with arylmethyl bromides/heteroarylmethyl bromides using t-BuOK as a base in DMF, followed by Pd(0)-mediated intramolecular Heck coupling in the presence of K2CO3 in DMF at 80-140 C. The attractive feature of this protocol is that a wide variety of pi-conjugated heterocycles could be readily accessed by an appropriate choice of arylmethylsulfones and benzylic bromides.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 1196-19-6. In my other articles, you can also check out more blogs about 1196-19-6
Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem