Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. SDS of cas: 4923-87-9. Introducing a new discovery about 4923-87-9, Name is 5-Bromobenzothiophene
RhCl3-Catalyzed Oxidative C-H/C-H Cross-Coupling of (Hetero)aromatic Sulfonamides with (Hetero)arenes
1,1?-Bi(hetero)aryl 2-sulfonamide scaffolds have been widely used as a privileged structure in drug discovery. Herein, we report an efficient rhodium-catalyzed oxidative C-H/C-H cross-coupling between a (hetero)aromatic sulfonamide and a (hetero)arene to afford ortho-sulfonamido bi(hetero)aryls. This methodology features broad substrate scope, good functional group tolerance, and relatively inexpensive catalyst (without the use of RhCp). A wide range of (hetero)arenes such as thiophenes, benzothiophenes, pyrroles, furans, benzofuran, indolizine, and simple arenes can engage in this transformation. This protocol also provides a facile route to bi(hetero)aryl sultams and dibenzo[b,d]thiophene 5,5-dioxides through further intramolecular cyclization, indicating its potential application in materials exploitation.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 4923-87-9, you can also check out more blogs about4923-87-9
Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem