In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 146137-92-0, name is Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, introducing its new discovery. Application In Synthesis of Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate
Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for beta-amyloid plaques
The synthesis and SAR of new beta-amyloid binding agents are reported. Evaluation of important properties for achieving good signal-to-background ratio is described. Compounds 27, 33, and 36 displayed desirable lipophilic and pharmacokinetic properties. Compound 27 was further evaluated with autoradiographic studies in vitro on human brain tissue and in vivo in Tg2576 mice. Compound 27 showed an increased signal-to-background ratio compared to flutemetamol 4, indicating its suitability as PET ligand for beta-amyloid deposits in AD patients. The preparation of the corresponding 18F-labeled PET radioligand of compound 27 is presented.
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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem