Analyzing the synthesis route of 17402-83-4

17402-83-4, 17402-83-4 Benzo[b]thiophen-4-amine 298484, abenzothiophene compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17402-83-4,Benzo[b]thiophen-4-amine,as a common compound, the synthetic route is as follows.

Example 8 N2-(1 ,1-dioxido-1-benzothien-4-yl)-N4-(5-fluoro-1 H-indazol-3-yl)-2,4-pyrimidinediamineA solution of N-(2-chloro-4-pyrimidinyl)-5-fluoro-1 H-indazol-3-amine (25.00 mg, 0.095 mmol) and 1-benzothien-4-ylamine (14.15 mg, 0.095 mmol) in N-Methyl-2-pyrrolidone (NMP) (474 pi) was treated with 2 drops of 2N HCI in Et20 and stirred at 100 ¡ãC for 20 hours. Solid NaHC03 was added followed by oxone (58.3 mg, 0.095 mmol), and a few drops of water. The reaction was stirred at rt for 20 hours. The reaction mixture was filtered through a 0.2 muetaeta ptfe frit and diluted with MeOH then purified via prep HPLC using a Sunfire 5 pm, 30×150 mm, C18 column eluting with 25-65percent MeCN/water (with 0.1 percent TFA) to give the title compound as the TFA salt. 1H NMR (DMSO-d6) delta : 12.97 (s, 1 H), 9.32 (s, 1 H), 9.18 (s, 1 H), 8.18 (s, 1 H), 7.68 (d, J = 5.6 Hz, 1 H), 7.59 (dd, J = 9.0, 4.2 Hz, 1 H), 7.55 (d, J = 5.6 Hz, 1 H), 7.42 (d, J = 7.8 Hz, 1 H), 7.25 – 7.37 (m, 3H), 6.57 (t, J = 8.0 Hz, 1 H).; MS (m/z) 409 (M+H+).

17402-83-4, 17402-83-4 Benzo[b]thiophen-4-amine 298484, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; CASILLAS, Linda, N.; CHAKRAVORTY, Subhas, J.; CHARNLEY, Adam, Kenneth; EIDAM, Patrick; HAILE, Pamela, A.; HUGHES, Terry, Vincent; JEONG, Jae, U.; KANG, Jianxing; LAKDAWALA SHAH, Ami; LEISTER, Lara, Kathryn; MARQUIS, Robert, W.; MILLER, Nathan, Andrew; PRICE, Daniel, J.; SEHON, Clark, L.; WANG, Gren, Z.; ZHANG, Daohua; WO2011/120025; (2011); A1;,
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Some tips on 130-03-0

130-03-0, As the paragraph descriping shows that 130-03-0 is playing an increasingly important role.

130-03-0, Benzo[b]thiophen-3(2H)-one is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of 60% NaH (O.l7moI) and HCOOEt (O.l3mol) in toluene (200m1), ketone (O.lmoI) was added dropwise at O-5C. Then mixture was stirred for 16h at rt. Then reaction mixture was evaporated to dryness, residue was dissolved in water and organic residues was extracted with MTBE from aquaeous solution. Then water was acidified with AcOH to pH<7 and product was extracted with EtOAc: 130-03-0, As the paragraph descriping shows that 130-03-0 is playing an increasingly important role.

Reference£º
Patent; THE UNIVERSITY OF BRITISH COLUMBIA; TCHERKASSOV, Artem; RENNIE, Paul, S.; SINGH, Kriti; MUNUGANTI, Ravi Shashi Nayana; (107 pag.)WO2016/165007; (2016); A1;,
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Analyzing the synthesis route of 4923-87-9

As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.,4923-87-9

General procedure: A mixture of compound 2a,b (1.17 mmol), 4-hydroxyphenylboronicacid (3, 1.45 mmol, 200 mg), cesium carbonate (2.34 mmol, 0.763 g),and dichloro-[1,1?-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P?]palladium (0.059 mmol, 0.038 g) in a mixture of dimethoxyethane(15 mL) and distilled water (10 mL) was flushed with nitrogen andheated at 90 C under nitrogen overnight. Once the reaction completionwas confirmed using TLC, the reaction mixture was evaporated invacuo, and the residue was partitioned between water (20 mL) andethyl acetate (3¡Á20 mL). The combined organic layer extracts weredried over anhydrous sodium sulfate and evaporated in vacuo to dryness.They were used as such in the next steps.

As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.

Reference£º
Article; Zaraei, Seyed-Omar; El-Gamal, Mohammed I.; Shafique, Zainab; Amjad, Sayyeda Tayyeba; Afridi, Saifullah; Zaib, Sumera; Anbar, Hanan S.; El-Gamal; Iqbal, Jamshed; Bioorganic and Medicinal Chemistry; vol. 27; 17; (2019); p. 3889 – 3901;,
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New learning discoveries about 95-15-8

The synthetic route of 95-15-8 has been constantly updated, and we look forward to future research findings.

95-15-8, Thianaphthene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,95-15-8

Step C: Synthesis of Compound 6; The compound 2 (13.420 g, 100.0 mmol) and a stir bar were placed in a 300-ml three-neck flask and nitrogen replacement was carried out in the reaction vessel. Next, anhydrous Et2O (200 ml) was added and the reaction vessel was cooled to -15 C. Then, n-BuLi (2.44M hexane solution, 40.98 ml, 110.0 mmol) was added and the mixture was stirred at -15 C. for 30 minutes. Next, elemental sulfur (7.697 g, 240.0 mmol) was slowly added and the mixture was stirred at a room temperature for 11 hours. Water was poured into the reaction mixture and hydrochloric acid was added to adjust the pH of the solution to 1.0. After being extracted with CH2Cl2, the organic layer was dried over anhydrous magnesium sulfate and filtered. Then, the solvent was removed by a rotary evaporator. The reaction mixture obtained was dissolved into 100 ml of tetrahydrofuran (THF). After slowly adding sodium tetrahydroborate (3.782 g, 100.0 mmol) at a room temperature, the mixture was stirred for 1 hour as it was. Next, water was poured into the reaction solution and hydrochloric acid was added to adjust the pH of the solution to 1.0. After being extracted with Et2O, an aqueous solution of 5.0M sodium hydroxide was added to the organic phase to make the mixture basic. Then, the aqueous phase was separated and hydrochloric acid was added to the aqueous phase to adjust its pH to 1.0. After being extracted with CH2Cl2, the organic layer was dried over anhydrous magnesium sulfate and filtered. Then, the solvent was removed by the rotary evaporator. Through silica gel column chromatographly using hexane as a developing solvent, the compound 6 (9.156 g, 55.07 mmol, 55%) was separated and purified as a white solid. Structural data of the compound were as follows: 1H NMR (400 MHz, CDCl3) delta 3.67 (d, 1H, J=1.0 Hz, SH), 7.26 (brs, 1H, ArH), 7.29 (dd, 1H, J=7.5, 1.7 Hz, ArH), 7.30 (dd, 1H, J=7.2, 1.4 Hz, ArH), 7.65 (dd, 1H, J=6.9, 2.0 Hz, ArH), 7.70 (dd, 1H, J=7.0, 1.8 Hz, ArH).

The synthetic route of 95-15-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SEIKO EPSON CORPORATION; US2008/76935; (2008); A1;,
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Downstream synthetic route of 4923-87-9

4923-87-9 5-Bromobenzothiophene 2776578, abenzothiophene compound, is more and more widely used in various fields.

4923-87-9,4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Bromobenzothiophene (1.60 g, 7.51 mmol) and dichloromethyl methyl ether (1.29 g, 11.3 mmol) were dissolved in anhydrous 1,2-dichloroethane (75 mL). Titanium tetrachloride (2.14 g, 11.3 mmol) was added, turning the solution dark. After one hour at room temperature, the reaction was poured into a mixture of saturated aqueous NaHCO3 and ice. The mixture was stirred for about 30 minutes and then was extracted with DCM (2¡Á100 mL). The extracts were concentrated and chromatographed (0 to 5% ethyl acetate in hexane) to yield 5-bromo-benzo[b]thiophene-3-carbaldehyde (1.32 g). The 5-bromobenzothiophene-3-carboxaldehyde (1.20 g, 4.98 mmol) and sulfamide (4.0 g, 42 mmol) were combined in anhydrous ethanol (25 mL) and heated to reflux for three days. The reaction was cooled to room temperature and sodium borohydride (0.207 g, 5.47 mmol) was added. After five hours, water (50 ml) was added and the solution was extracted with chloroform (3¡Á50 mL). The extracts were concentrated, suspended in a minimal amount of DCM, and filtered to provide the title compound as a yellow solid.1H NMR (DMSO-d6): delta 8.12 (1H, d, J=1.8 Hz), 7.97 (1H, d, J=8.6), 7.71 (1H, s), 7.52 (1H, dd, J=8.6, 1.9 Hz), 7.12 (1H, t, J=6.3 Hz), 6.72 (2H, s), 4.28 (2H, d, J=6.2 Hz).

4923-87-9 5-Bromobenzothiophene 2776578, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Smith-Swintosky, Virginia L.; US2007/191461; (2007); A1;,
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Analyzing the synthesis route of 5381-20-4

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

5381-20-4,5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Dehydroacetic acid (500 mg, 2.97 mmol),3-formaldehyde benzothiophene (482.34 mg, 2.97 mmol) was dissolved in CHCl3 (4 ml).Piperidine (2d) was added dropwise,Nitrogen protection, reaction at 60 C for 12 h.The post-processing operation is the same as in Embodiment 1,A yellow solid was obtained, 507 mg (yield 54.59%).

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Jiangsu Hengrui Pharmaceutical Co., Ltd.; You Qidong; Hu Wenyuan; Jiang Zhengyu; Guo Xiaoke; Xu Xiaoli; Zhang Xiaojin; (14 pag.)CN107629041; (2018); A;,
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Downstream synthetic route of 3541-37-5

3541-37-5, As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: An aldehyde (3.24 mmol) was dissolved in EtOH (12 mL), then a solution of NH2OH*HCl (360 mg, 5.18 mmol) and Na2CO3 (247 mg,2.33 mmol) in water (3 mL) was added, and the mixture was boiled at reflux temp for 20 min. Saturated aqueous NaCl solution (30 mL)was added, and the mixture was extracted by EtOAc (2 20 mL).The combined organic layers were dried (MgSO4) and evaporated to give the expected aldoxime which was used without further purification.

3541-37-5, As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Goyard, David; Konya, Balint; Chajistamatiou, Aikaterini S.; Chrysina, Evangelia D.; Leroy, Jeremy; Balzarin, Sophie; Tournier, Michel; Tousch, Didier; Petit, Pierre; Duret, Cedric; Maurel, Patrick; Somsak, Laszlo; Docsa, Tibor; Gergely, Pal; Praly, Jean-Pierre; Azay-Milhau, Jacqueline; Vidal, Sebastien; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 444 – 454;,
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Some tips on 5381-20-4

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, A mixture of 2-aminohistamine (0.11 mmol) and 3-benzothiophene carboxaldehyde (0.13 mmol) was stirred in ethanol at room temperature for 6 h, after which 10% PdVC (24 mg) was added and the reaction mixture refluxed for a further 24 h. The mixture was then filtered through a celite pad, washed with ethanol (3 x 25 mL) and5 toluene (2 x 20 mL). The combined filtrates were concentrated under reduced pressure and chromatographed over silica gel using a gradient of 5:95 – 20:80 giving pure 4- (benzothiophen-3-yl)-lH-imidazo[4,5-c]pyridin-2-amine (22.2 mg; 76%) as a white solid. 1H NMR (400 MHz, CD3OD) delta 8.29 (s, IH), 8.27 (d, J = 6.5 Hz, IH), 8.10-8.07 (m, IH), 7.79-7.75 (m, IH), 7.60 (d, J= 6.5 Hz, IH), 7.55-7.48 (m, 2H). 0

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MACQUARIE UNIVERSITY; WO2009/152584; (2009); A1;,
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Analyzing the synthesis route of 5381-20-4

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.,5381-20-4

General procedure: As a typical experiment, the reaction of the aryl bromide (1 mmol), benzothiophene (1.5 mmol) and KOAc (0.196 g, 2 mmol) at 150C during 16 h in DMF or DMAc (4 mL) in the presence of Pd(OAc)2 (0.224 mg,0.001 mmol) or (1.12 mg, 0.005 mmol) prepared as a solution in DMAc (1 mg of Pd(OAc)2 in 1 mL of DMAc) under argon affords the coupling product after evaporation of the solvent and purificationon silica gel.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Zhao, Liqin; Bruneau, Christian; Doucet, Henri; Tetrahedron; vol. 69; 34; (2013); p. 7082 – 7089;,
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Analyzing the synthesis route of 360576-01-8

360576-01-8, As the paragraph descriping shows that 360576-01-8 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360576-01-8,Methyl 6-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

12144] A mixture of 900 mg of methyl 6-bromobenzo[b] thiophene-2-carboxylate, 2.28 ml of diisopropylamine, 116 mg of dichlorobis(triphenylphosphine)palladium (II), 32mg of copper iodide (1), 0.92 ml of trimethylsilyl acetylene, and 15 ml of toluene was stirred for 20 hours at room temperature under a nitrogen atmosphere. The reaction mixture was concentrated under reduced pressure, hexane was added to the residues, and insoluble matter was separated by filtration. The filtrate was concentrated under reduced pressure, and the residues were subjected to silica gel colunm chromatography, thereby obtaining 590mg ofmethyl 6-(trimethylsilylethynyl) benzo[b]thiophene-2-carboxylate.

360576-01-8, As the paragraph descriping shows that 360576-01-8 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
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