Day: November 24, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-03-0,Benzo[b]thiophen-3(2H)-one,as a common compound, the synthetic route is as follows.

To a 5 mL flame-dried microwave flask was added benzo[b]thiophen-3(2H)-one (0.24 mmol, 0.12 equiv) and 5-aryl-2-formylpyrrole (0.2 mmol, 0.1 equiv). The flask was capped with analuminume-PTFE crimp cap, sealed, and evacuated and backfilled with nitrogen three times. To the flask was then added anhydrous toluene (2 mL, 0.1M in aldehyde) and piperidine (10 mL, 0.1 mmol,0.5 equiv). The flask was transferred to a pre-warmed oil bath set to 111 C and stirred for 2 h. After 2 h the flask was removed from theoil bath and cooled to room temperature and then to 0 C in a water-ice bath. To the flask was added hexanes (5 mL) and the flask was allowed to sit for an addition 10-30 min. The mixture was the filtered, and the precipitate was then triturated with hexanes to until the filtrate ran clear to provide the pure product as a red, blue,or purple solid depending on the substrate.

130-03-0, As the paragraph descriping shows that 130-03-0 is playing an increasingly important role.

Reference£º
Article; Zweig, Joshua E.; Ko, Tongil A.; Huang, Junrou; Newhouse, Timothy R.; Tetrahedron; vol. 75; 34; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20532-33-6,5-Chlorobenzothiophene,as a common compound, the synthetic route is as follows.

Preparation 25 3-Bromo-5-Chlorobenzothiophene To a solution of 0.30 gm (1.77 mMol) 5-chlorobenzothiophene 1.0 mL acetic acid was added a solution of 0.31 gm (1.95 mMol) bromine in 1.0 mL acetic acid under a nitrogen atmosphere. The reaction was heated to 50 C. for 4 hours at which time the volatiles were removed under reduced pressure. The residue was partitioned between dichloromethane and aqueous sodium bicarbonate. The phases were separated and the organics were washed with saturated aqueous sodium chloride, dried over sodium sulfate and concentrated under reduced pressure to give 0.335 gm (76%) of the title compound as a tan solid. m.p.=85-86 C. MS(FD): m/e=249 (M+2).

20532-33-6, The synthetic route of 20532-33-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eli Lilly and Company; US6358972; (2002); B1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, To dry ethanol (20 mL) was added benzo[b]thiophene-3-carbaldehyde (246 mg, 1.52 mmol) and sodium borohydride (115 mg, 3.03 mmol), and the reaction was stirred at room temperature for 90 mins. When the reaction was complete by TLC, excess sodium borohydride was quenched with sodium hydroxide solution (1%, 20 mL), and the reaction was extracted with ethyl acetate (3 ¡Á 20 mL) before being dried (MgSO4), filtered and concentrated in vacuo to yield the title product in quantitative yield (249 mg). Rf = 0.40 (5:2 petroleum ether: ethyl acetate); 1H NMR (300 MHz, CDCl3): deltaH = 7.90 – 7.83 (2H, m, Ar), 7.44 – 7.34 (3H, m, Ar), 4.92 (2H, s, CH2), 1.95 (1H, br s, OH); 13C NMR (75 MHz, CDCl3) deltaC = 140.87 (Ar), 137.75 (Ar), 136.04 (Ar), 124.69 (Ar), 124.32 (Ar), 123.95 (Ar), 122.99 (Ar), 122.05 (Ar), 59.88 (CH2); MS (EI): m/z 164 (M).

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Sherer, Christopher; Tolaymat, Ibrahim; Rowther, Farzana; Warr, Tracy; Snape, Timothy J.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 7; (2017); p. 1561 – 1565;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.,5381-20-4

Thianaphthene-3-carboxaldehyde (1.62 g, 10.0 mmol) was dissolved in anhydrous ethanol (50 mL). Sulfamide (4.0 g, 42 mmol) was added and the mixture was heated to reflux for 16 hours. The mixture was cooled to room temperature. Sodium borohydride (0.416 g, 11.0 mmol) was added and the mixture was stirred at room temperature for three hours. The reaction was diluted with water (50 mL) and extracted with chloroform (3*75 mL). The extracts were concentrated and chromatographed (5% methanol in DCM) to yield the title compound as a white solid. 1H NMR (DMSO-d6): delta 7.98 (1H, dd, J=6.5, 2.3 Hz), 7.92 (1H, dd, J=6.6, 2.4 Hz), 7.62 (1H, s), 7.36-7.45 (2H, m), 7.08 (1H, t, J=6.3 Hz), 6.72 (2H, s), 4.31 (2H, d, J=6.3 Hz).

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Patent; Smith-Swintosky, Virginia L.; Parker, Michael H.; Reitz, Allen B.; Maryanoff, Bruce E.; US2007/293476; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under an argon atmosphere, Pd(OAc)2 (3.3 mg, 0.015 mmol, 5 mol%),ligand [1,1?-biphenyl]-2-yldiphenylphosphane (15 mg, 0.045 mmol,15 mol%), HCO2NH4 (23 mg, 0.36 mmol), MeCO2NH4 (35 mg, 0.45mmol), benzopheneone N-tosylhydrazone 5a (126 mg, 0.36 mmol),and Cs2CO3 (195 mg, 0.6 mmol) were successively added to a flamedried flamedried25 mL Schlenk flask. The reaction flask was degassed threetimes with argon and anhyd tert-pentyl alcohol (3.0 mL) was addedusing a syringe. Then 1-bromo-4-(tert-butyl)benzene (2b; 64 mg, 0.3mmol) was added with a syringe. Note that the aryl bromide in a solidform was added to the reaction flask prior to Cs2CO3. The reactionwas heated at 90 C with stirring for about 4 h, then it was cooled tor.t., and filtered through a short pad of neutral alumina with EtOAc(25 mL) as eluent. Solvent was then removed in vacuo to leave a crudemixture, which was purified by silica gel column chromatography(eluent: PE); yellow solid (82 mg, 91%).

4923-87-9, As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.

Reference£º
Article; Xia, Yamu; Hu, Fangdong; Xia, Ying; Liu, Zhenxing; Ye, Fei; Zhang, Yan; Wang, Jianbo; Synthesis; vol. 49; 5; (2017); p. 1073 – 1086;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 1e (3.50 g, 23.46 mmol) and Compound 1f (4.28 g, 23.46 mmol) were dissolved in 1,2-dichloroethane (250 mL), and trifluoroacetic acid (70 mg, 0.62 mmol) was added. The reaction mixture was stirred for 16 hr at 50 C. The reaction mixture was washed with a saturated solution of sodium bicarbonate (250 mL), and extracted with dichloromethane (150 mL¡Á2). The organic phases were combined, dried over anhydrous sodium sulfate, filtered, concentrated under reduced pressure to dryness, and separated and purified by flash silica gel column chromatography (petroleum ether/ethyl acetate 100-60%) to give Compound 1g (4.4 g, yellow solid, yield: 36%). MS-ESI calculated value [M+ H]+ 314, measured value 314.

1127-35-1, The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; YAO, Yuanshan; CHEN, Bin; CHEN, Yuan; LI, Ao; XU, Ran; HUANG, Zhensheng; TIAN, Dongdong; LI, Hongwei; YANG, Chengshuai; LI, Jian; CHEN, Shuhui; (102 pag.)EP3489233; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20532-33-6,5-Chlorobenzothiophene,as a common compound, the synthetic route is as follows.

5-Chlorobenzothiophene was prepared by procedures known in the art (J. Heterocyclic Chem. 1988, 25, 1271). 1.68 g (9.96 mmol) of the compound were dissolved in 20 ml dry ether, and the solution was kept under argon at room temperature, while 6.25 ml (10 mmol) of a 1.6 M solution of butyl lithium in hexane was added dropwise. It was stirred for 30 min, cooled to -30 C. followed by slow addition of 1.60 g (10.0 mmol) bromine. After 30 min stirring at this temperature cooling was stopped, and the mixture was washed with aqueous sodium thiosulfate solution. The organic layer was dried over sodium sulfate and concentrated under reduced pressure, and the title benzothiophene was obtained after chromatography on silica gel with hexane to give 1.65 g (67%) of a colorless oil, which slowly solidified.

20532-33-6, 20532-33-6 5-Chlorobenzothiophene 11309754, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Takeuchi, Kumiko; Jirousek, Michael Robert; Paal, Michael; Ruhter, Gerd; Schotten, Theo; US2004/9976; (2004); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 168 (1.259 g, 5.31 mmol) and compound 61 (1.00 g, 4.83 mmol) were dissolved in DMF (6.0 mL). EDC?HC1 (1.11 g, 0.476 mmol) and DMAP (0.295 g, 2.41 mmol) were added. The reaction mixture was allowed to stir at ft under Ar overnight. After stirring overnight, DI water (25 mL) was added to the reaction mixture to precipitate the product. The slurry was stirred at ft for 5 mm and was then filtered. The resulting solids were placed on high vacuum to dryness to give crude 169, which was used directly in the next step (2.058 g, 5.31 mmol, 100% yield). UPLCMS (2.5 mm method) = 1.84 mm. Mass observed (ESI): 427.2 (M+H)., 20699-85-8

Big data shows that 20699-85-8 is playing an increasingly important role.

Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; CHARI, Ravi, V.J.; (312 pag.)WO2019/133652; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22913-24-2,Methyl benzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

Under N2 atmosphere, an oven-dried 4 mL vial was charged with methyl benzo[b]thiophene-2-carboxylate (27.7 mg, 0.300 mmol, 1.00 equiv), palladium complex 1 (11.4 mg, 15.0 mupiiotaomicron, 5.00 mol%), Ag(bipy)2C104 (16.0 mg, 30.0 mupiiotaomicron, 10.0 mol%), and NFBS (0.189 g, 0.600 mmol, 2.00 equiv). Acetonitrile (0.75 mL, c = 0.40 M) was added and the reaction mixture was stirred in a sealed vial at 4 C for 24 h. Subsequently, triethylamine (30.5 mg, 42.0 mu, 0.300 mmol, 1.00 equiv) was added and the reaction mixture was concentrated in vacuo. The residue was purified by chromatography on silica gel, eluting with hexanes/EtOAc (19: 1 to 4: 1 (v/v) with 1% triethylamine), to afford 115 mg of the title compound as a colorlesssolid (79% yield). [00237] R/= 0.38 (hexanes/EtOAc 7:3 (v/v)). NMR Spectroscopy: 1H NMR (600 MHz, CDC13, 23 C, delta): 7.98-8.00 (m, 4H), 7.83 (d, J = 8.2 Hz, 1H), 7.66-7.70 (m, 2H), 7.53 (t, J = 7.9 Hz, 4H), 7.46 (td, J = 1.6, 1.2 Hz, 1H), 7.30-7.33 (m, 1H), 7.25-7.28 (m, 1H), 3.39 (s, 3H). 13C NMR (125 MHz, CDC13, 23 C, delta): 160.9, 139.8, 138.2, 137.4, 134.6, 134.2, 129.4, 128.9, 128.8, 127.8, 125.4, 124.8, 122.8, 52.3. Mass Spectrometry: HRMS (ESI-TOF) (m/z): calcd for C22H2iN206S3 [M + NH4]+, 505.0556, found, 505.0569., 22913-24-2

The synthetic route of 22913-24-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; NGAI, Ming-Yu; BOURSALIAN, Gregory, Bagrad; MCNEILL, Eric, Andrew; RITTER, Tobias; WO2015/31725; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

6314-28-9,6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Benzo [b] thiophene-2-carboxylic acid (159 mg, 0.892 mmol), 2-amino-biphenyl (156 mg, 0.922 mmol), DCC (393 mg, 1.90mmol) and DMAP (26 mg, 0.21 mmol) It was dissolved in dichloromethane (20 mL), and stirred for 14 hours at room temperature. when thin layer chromatography (TLC) check when, a new spot is generated, and then adding water to the reaction mixture, dichloromethane comingAnd extracted twice with. The extracted organic layer was dried over magnesium sulfate and concentrated under reduced pressure. Column The concentrated reaction mixture was purified by chromatography (silica gel, ethyl acetate / n- hexane = 1/9) to obtain the object compound (102 mg, 35%) as a white solid.

6314-28-9 Benzo[b]thiophene-2-carboxylic acid 95864, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; JUNG, YOUNG SIK; KIM, PIL HO; HAN, SOO BONG; RAGHAVENDRA, ACHARY; KIM, MEE HYEIN; LEE, CHONG KYO; SHIN, JIN SOO; (131 pag.)KR2015/25531; (2015); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem