4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 5-bromobenzothiophene (12, 11.5 g, 45.1 mmol) in toluene (150 mL) under argon was added palladium acetate (0.84 g, 3.75 mmol), P(iBuNCH2CH2)3N (2.6 g, 7.6 mmol), and sodium tert-butoxide (5.4 g, 56.3 mmol). The reaction mixture was stirred for 2 min at room temperature, and then 7-bromodihydroisoquinolinone (11, 9.0 g, 37.5 mmol) was added. The resultant solution was heated at 70 C for 30 min, and then it was cooled to room temperature. The reaction was quenched with aqueous ammonium chloride and extracted with dichloromethane. The organic extract was washed with brine, dried over sodium sulfate, and concentrated in vacuo. The residue obtained was purified by flash column chromatography (eluent: 80/20 dichloromethane/EtOAc) to give the desired 4-(5-benzothiophen-yl)dihydroisoquinolinone (13, 8.84 g, 63%) as a light yellow foam.
4923-87-9, The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Hu, Min; Guzzo, Peter R.; Zha, Congxiang; Nacro, Kassoum; Yang, Yuh-Lin; Hassler, Carla; Liu, Shuang; Tetrahedron Letters; vol. 53; 7; (2012); p. 846 – 848;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem