6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
6314-28-9, Thionyl chloride (0.81 mL, 11.1 mmol) was added to a solution of benzo[b]thiophene-2-carboxylic acid 3 (0.4 g, 2.24 mmol), in pyridine (0.3 mL, 1.8 mmol) and toluene (15 mL, 14.1 mmol) at reflux. The reaction mixture was quenched in ice water and the toluene evaporated in vacuo. The acid chloride was extracted with distilled DCM (2¡Á25 mL, 2¡Á10 mL) and the combined organic extracts washed with distilled water (2¡Á20 mL) and dried. The solvent was evaporated under reduced pressure to give a brown residue, which was purified using flash chromatography with DCM as the eluent to yield 11a17 (0.27 g, 61%) as a colourless solid. 1H NMR (CDCl3, 300 MHz): delta 7.50 (m, 2H), 7.91 (m, 2H), 8.27 (s, 1H). 13C NMR: delta 123.1 (C3), 125.9 (C7), 126.9 (C4), 128.9 (C5 and C6), 136.1 (C2), 138.3 (C3a), 144.3 (C7) and 161.9 (CO). MS (CI+), m/z 197, 199 [MH+1, 35Cl, 37Cl].
The synthetic route of 6314-28-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Mbere, Johana M.; Bremner, John B.; Skelton, Brian W.; White, Allan H.; Tetrahedron; vol. 67; 36; (2011); p. 6895 – 6900;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem