With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.
6314-28-9, To a CH2CI2 (70 ml_, 0.2 M) solution of 1 ,1 -dim ethyl ethyl (3R.4R)- 3-hydroxy-4-[(L-leucylamino)methyl]-1-pyrrolidinecarboxylate (4.6 g, 14.1 mmol) was added i-benzothiophene-2-carboxylic acid (2.76 g, 15.5 mmol ), EDC (3.24 g, 16.9 mmol), HOOBt (0.46 g, 2.82 mmol) and NMM (3.8 ml_, 35.26 mmol), and the mixture was stirred at room temperature overnight. The reaction mixture was quenched by the addition of 1 N HCI, and the phases were separated. The organic solution was washed sequentially with saturated NaHCO3 and brine, dried (Na2SO4), filtered and concentrated to give crude product. Purification by silica chromatography (40 – 100% ethyl acetate/hexanes) gave the title compound as a white foam in 87% yield (6.0 g). LCMS (m/z): 490 (M+H)+.
6314-28-9 Benzo[b]thiophene-2-carboxylic acid 95864, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/82262; (2007); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem