With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22913-24-2,Methyl benzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
A ruthenium complex (3.0 mg, 5.6 mumol) was sequentially added to a 5 mL sealed tube with a stirrer, and the ester substrate was added.(0.56 mmol), B2pin2 (0.14 g, 0.56 mmol) and 1 mL of tetrahydrofuran.Next, the 5 mL sealed tube was screwed and removed from the glove box and placed under an oil bath at 120 C to heat and stir the reaction for 12 hours. When the reaction solution is cooled to room temperature, it is quenched with ethyl acetate.The low boiling organics should then be drained on a rotary evaporator. Finally, add an equimolar amount of dibromomethane to the substrate asThe internal standard measures the nuclear magnetic yield of the product, and after obtaining the nuclear magnetic yield, the low-boiling organic matter in the crude product is again removed, and finally,The column is separated and purified. Light yellow oil, the eluent used in the column was ethyl acetate: petroleum ether = 1:80-1:40. product1H NMR yield: 70%, isolated yield: 47%, 42 mg.
22913-24-2, The synthetic route of 22913-24-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Taizhou University; Yao Wubing; Huang Xiangyun; Yu Meimei; (11 pag.)CN107936047; (2018); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem