With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
A mixture of 300 mg of methyl 5-aminobenzo[b]thiophene-2-carboxylate, 316 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 275 mg of benzoic acid, 18 mg of N,N-dimethyl-4-aminopyridine, and 10 ml of tetrahydrofuranwas stirred for 24 hours at room temperature. The reaction mixture was concentrated under reducedpressure, and tert-butyl methyl ether was added to the residues. The organic layer was washed with 1 M aqueoushydrochloric acid solution, 1 M aqueous sodium hydrogen carbonate solution, and saturated saline, dried over magnesiumsulfate, and concentrated under reduced pressure, thereby obtaining 318 mg of methyl 5-(benzoylamino)benzo[b]thiophene-2-carboxylate., 20699-85-8
The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sumitomo Chemical Company Limited; MUKUMOTO, Fujio; TAMAKI, Hiroaki; KUSAKA, Shintaro; IWAKOSHI, Mitsuhiko; EP2926660; (2015); A1;,
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