With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.
95-15-8, A. 2,3-Dibromobenzo[b]thiophene STR16 Benzothiophene (26.8 g, 0.2 mol) was dissolved in 150 mL CHCl3 and treated with a solution of bromine (64 g, 0.4 mol) in 75 mL CHCl3 dropwise over an hour. The reaction was allowed to stir overnight then cautiously quenched with saturated aqueous Na2 CO3 until no gas evolution was evident. The layers were separated and the organic layer was first washed with saturated aqueous Na2 CO3 then with water. It was dried over MgSO4 and concentrated under vacuum to a solid. Recrystallized from MeOH to obtain 16.5 g (57 mmol, 28%) of a white fluffy solid. 1 H NMR (CDCl3) delta7.77-7.71 (m, 2H), 7.46-7.38 (m, 2H).
As the paragraph descriping shows that 95-15-8 is playing an increasingly important role.
Reference£º
Patent; Eli Lilly and Company; US6133262; (2000); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem