With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-03-0,Benzo[b]thiophen-3(2H)-one,as a common compound, the synthetic route is as follows.
To AN-1 (6 g, 3.99 mmol)N2H4 hydrate (31.1 ml) was added to a solution in EtOH (60 mL).The mixture was heated to reflux and held for 45 min.The mixture was allowed to cool to rt and then concentrated.The residue was dissolved in diethylene glycol (20 mL) and EtOAc (EtOAc.The mixture was stirred at 120 C for 18 h.The mixture was cooled to rt, diluted with EtOAc and pH was adjusted to pH < 4 with 1 N HCl. The organic layer was washed with brine, dried over Na2EtOAcThe residue was purified by flash chromatography on SiO2 to yield AN-2. 130-03-0, As the paragraph descriping shows that 130-03-0 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BAKONYI,JOHANNA; BRUNETTE,STEVEN RICHARD; COLLIN,DELPHINE; HUGHES,ROBERT OWEN; LI,XIANG; LIANG,SHUANG; SIBLEY,ROBERT; TURNER,MICHAEL ROBERT; WU,LIFEN; ZHANG,QIANG; (169 pag.)TW2018/38997; (2018); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem