5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5381-20-4, General procedure: Method A. As a representative procedure, to an acetone (3.6 mL, 20 equiv) solution of 1-benzothiophene-2-carbaldehyde 1a (0.5 g, 3.00 mmol) at 0 C, cat. II (41 mg, 0.30 mmol, 0.1 equiv) was added in one portion. The mixture was stirred for 12 h at this temperature, and the resulting solution was treated with a solution of NH4Cl aq (15 mL) and extracted with EtOAc (20 mL). The organic phase was dried with Na2SO4 and concentrated under reduced pressure after filtration. The yellow crude solid was chromatographed using petroleum ether/EtOAc 70:30 to afford the corresponding aldol adduct 2a as a white solid (0.58 g, 89% yield). Method B. As a representative procedure, to an acetone (6.8 mL, 20 equiv) solution of benzo[b]thiophene-2-carbaldehyde 1a (1.0 g, 6.10 mmol) at 0 C, cat. III (154 mg, 0.61 mmol, 0.1 equiv) was added in one portion. The mixture was stirred for 12 h at this temperature, and the resulting solution was treated with a solution of NH4Cl aq (15 mL) and extracted with EtOAc (20 mL). The organic phase was dried with Na2SO4 and concentrated under reduced pressure after filtration. The yellow crude solid was chromatographed using petroleum ether/EtOAc 70:30 to afford the corresponding aldol adduct 2a as a white solid (1.12 g, 84% yield).
The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Secci, Francesco; Cadoni, Enzo; Fattuoni, Claudia; Frongia, Angelo; Bruno, Giuseppe; Nicolo, Francesco; Tetrahedron; vol. 68; 24; (2012); p. 4773 – 4781;,
Benzothiophene – Wikipedia
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