With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.
95-15-8, A. 2,3-Dibromobenzo[b]thiophene. Benzothiophene (26.8 g, 0.2 mol) was dissolved in 150 mL CHCl3and treated with a solution of bromine (64 g, 0.4 mol) in 75 mL CHCl3dropwise over an hour. The reaction was allowed to stir overnight then cautiously quenched with saturated aqueous Na2CO3until no gas evolution was evident. The layers were separated and the organic layer was first washed with saturated aqueous Na2CO3then with water. It was dried over MgSO4and concentrated under vacuum to a solid. Recrystallized from MeOH to obtain 16.5 g (57 mmol, 28%) of a white fluffy solid. 1H NMR (CDCl3) delta 7.77-7.71 (m, 2H), 7.46-7.38 (m, 2H).
95-15-8 Thianaphthene 7221, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Patent; ELI LILLY AND COMPANY; EP997460; (2000); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem