6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of thieno[3,2-b]pyridine-7-carboxylic acid10(568 mg, 3.18 mmol) and tert-butyl 4-(4-((4-aminopiperidin-1-yl)methyl)-2-bromophenoxy)piperidine-1-carboxylate15(109 mg, 0.24 mmol) in DMF (5 mL) were added bis(2-oxo-3-oxazolidinyl)phosphinic chloride(BOP-Cl, 84 mg, 0.33 mmol) and triethylamine (0.092 ml, 0.66 mmol). After being stirred at room temperature for 16 h, the mixture was diluted with water (30 mL), and extracted with ethyl acetate (30 mL x 2). The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated in vacuo, giving a residue that was subjected to column chromatography on silica gel (3% MeOH/CH2Cl2) to afford 112 mg (82%) of the boc-protected compound11.1H NMR (300 MHz, CDCl3)delta7.79-7.89 (m, 2H), 7.75 (s, 1H), 7.53 (s, 1H), 7.35-7.45 (m, 2H), 7.17 (d,J= 8.4 Hz, 1H), 6.86 (d,J= 8.4 Hz, 1H), 6.02 (d,J= 7.8 Hz, NH), 4.50-4.60 (m, 1H), 3.94-4.08 (m, 1H), 3.58-3.70 (m, 2H), 3.43-3.55 (m, 2H), 3.43 (s, 2H), 2.80-2.90 (m, 2H), 2.11-2.22 (m, 2H), 2.00-2.10 (m, 2H), 1.81-1.91 (m, 4H), 1.51-1.69 (m, 2H), 1.47 (s, 9H)., 6314-28-9
The synthetic route of 6314-28-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Lim, Chae Jo; Woo, Seong Eun; Ko, Su Ik; Lee, Byung Ho; Oh, Kwang-Seok; Yi, Kyu Yang; Bioorganic and Medicinal Chemistry Letters; vol. 26; 19; (2016); p. 4684 – 4686;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem