With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.
Benzo[]thiophene-2-thiol (72): Compound 71 (1.75 g,13.0 mmol) was dissolved in 40 niL of dry Et2O under N2 and the solution was cooled to -4O0C. nBuLi (2.5 M solution in hexane, 5.7 mL, 14.3 mmol) was added and the reaction mixture was allowed to warm up to O0C during Ih and then sulfur (0.414g, 13.0 mmol) was added in one portion. The solution was allowed to slowly warm up to RT over 3 h. Excess of 10% HCl was added and the reaction mixture was stirred for 20 min. The thiol was extracted with ether, washed with brine, dried over Na2SO4 and concentrated to afford 2.0 g of crude compound 72 which was used in the next step without further purification., 95-15-8
95-15-8 Thianaphthene 7221, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Patent; HYDRA BIOSCIENCES, INC.; WO2006/122156; (2006); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem