10133-22-9, 5-(Bromomethyl)benzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparative Example 49PREPARATION OF 5-VINYL-1-BENZOTHIOPHENETriphenylphosphine (1.20 g, 4.58 mmol) and 5-(bromomethyl)-1-benzothiophene (1.00 g, 4.40 mmol) in toluene (50 mL) was heated under reflux for 2 h. The mixture was then cooled and the resulting white crystalline precipitate was isolated by suction filtration, rinsed with a small amount of hexanes, and dried in vacuo. The solid was suspended in aqueous formaldehyde (37%, 20 mL) and aqueous sodium hydroxide (3M, 10 mL) was added dropwise. The resulting mixture was stirred for 3 h at r.t. It was then extracted with hexanes, dried (MgSO4), and concentrated under reduced pressure. Column chromatography of the residue (hexanes) afforded the product.1H NMR (400 MHz, CDCl3) delta (ppm): 7.83-7.80 (m, 2H); 7.48-7.42 (m, 2H); 7.31 (dd, J=5.2, 0.8, 1H); 6.83 (dd, J=17.0, 11.0, 1H); 5.82 (d, J=17.4, 1H); 5.28 (d, J=11.0, 1H).
10133-22-9, The synthetic route of 10133-22-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MethylGene Inc.; US2010/279983; (2010); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem