With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
A solution of 4-(4-(((6aS)-5-((allyloxy)carbonyl)-2-methoxy- 12-oxo-6-((tetrahydro-2H- pyran-2-yl)oxy)-5,6,6a,7,8,9,10,12-octahydrobenzo[e]pyriclo[1,2-a] [1,4]diazepin-3- yl)oxy)butanamido)-1-methyl-1H-imidazole-2-carboxylic acid (15) (no mg, 0.17 mmol)in N,N-dimethylformamide (4 mL) was charged with 1-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride (s? mg, 0.31 mmol) and 4-(dimethylamino)pyridine (7 mg, 0.38 mmol). The reaction mixture was stirred at room temperature for 30 mm. Methyl 5-aminobenzo[b]thiophene-2-carboxylate (32 mg, 0.15 mmol) was then added and the resulting mixture was stirred at room temperature for 16 h. This was thenpoured into ice-water (40 mL) and extracted with ethyl acetate ( x 100 mL). The combined organic extracts were sequentially washed with 1 M citric acid (60 mL), a saturated aqueous solution of sodium hydrogen carbonate (70 mL), water (70 mL) and brine (70 mL). The organic layer was then dried over sodium sulfate, filtered and concentrated. The resulting residue was then purified by column chromatography(silica), eluting with ethyl acetate/dichloromethane (o% to 100%), followed by methanol/dichloromethane (from o% to 10%), to give the title compound (so mg, 39%) as a yellow oil.MS m/z (ElMS) = 844.9 (M+H) LCMS (Method A): tR = 8.22 mm., 20699-85-8
The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FEMTOGENIX LIMITED; JACKSON, Paul Joseph Mark; THURSTON, David Edwin; RAHMAN, Khondaker Mirazur; (121 pag.)WO2017/32983; (2017); A1;,
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