1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In some embodiments (Scheme 3), in a 50 mL round-bottom flask, 7-bromo- benzo[Z?]thiophene (0.213 g,l mmol) and Pd(PPh3)4 (0.116 g, 0.1 mmol) are suspended in THF (3 mL), then zinc reagent (6 mL, 3 mmol) is added with syringe. The reaction is stirred at 60 C for three hours, then the reaction mixture is cooled to room temperature, solvent is removed, EtOAc (30 mL) is added, and the mixture washed with 2 N NaOH solution (20 mL x 2). The organic layer is dried with Na2S04 and concentrated. The crude product is purified by ISCO silica column using 0-25% EtOAc in hexanes to yield 49 mg (20.9% yield) desired product methyl (2S)-3-(l- benzothiophen-7-yl)-2-methylpropanoate. NMR. (499 MHz, CDC13) delta 7.70 (dd, J= 7.9, 1.1 Hz, 1H), 7.43 (d,J=5.4Hz, 1H), 7.36 (d,J= 5.4 Hz, 1H), 7.31 (t,J=7.6 Hz, 1H), 7.15 (d, J= 7.2 Hz, 1H), 3.66 (s, 3H), 3.35(dd,J = 13.9, 6.8 Hz, 1H), 3.12 – 3.00 (m, 1H), 2.93 (dd,J= 14.0,8.0 Hz, 1H), 1.21 (d,J=7.0Hz, 3H).
1423-61-6, As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.
Reference£º
Patent; RIDEOUT, Darryl; LEDERMAN, Seth; DAUGHERTY, Bruce; GERSHELL, Leland, J.; (643 pag.)WO2016/105448; (2016); A1;,
Benzothiophene – Wikipedia
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