3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
a.) 3-Benzo[b]thiophen-2-yl-acrylic acid tert-butyl ester (Scheme 3); Potassium bis(trimethylsilyl)amide (5.4 g, 0.027 mol) was added to a solution of 18- Crown-6 (13.7 g, 0.052 mol ) and (diphenoxy-phosphoryl)-acetic acid tert-butyl ester (9.4 g, 0.027 mol) in dry THF (120 ml_) at -78 0C. After 30 minutes of stirring at this temperature, benzo[b]thiophene-2-carbaldehyde (4.0 g, 0.024 mol) was added and the reaction was stirred for 3 hours at -78 0C after which the reaction was quenched with saturated ammonium chloride (200 mL). The reaction mix was allowed to come to room temperature and was extracted with ethyl acetate (3 X 200 mL) and the combined organic extracts were washed with 10 % HCI (200 mL), brine (200 mL), and dried over MgSO4. The solvent was evaporated in vacuo leaving the crude product that was purified by column chromatography (Sitheta2) using a 5-40 % ethylacetate-hexane gradient to afford the subtitle compound (4.64 g, yield: 74 %). MS calculated for C15Hi6O2S +H: 261 , observed: 261.
3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Patent; ATHERSYS, INC.; WO2006/28961; (2006); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem