With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4965-26-8,5-Nitrobenzo[b]thiophene,as a common compound, the synthetic route is as follows.
5-Nitro-1-benzothiophene (1.70g, 9.49mmol) was hydrogenated in ethanol (34ml) under 3atm of H2 in the presence of 5% Pd/C (0.17g). After removal of the catalyst by filtration, the filtrate was concentrated in vacuo to give an amino derivative. This compound was methylated using the procedure described by Crochet et al.41 The crude product thus obtained was treated with 2-chloronicotinoyl isothiocyanate (9) prepared from 2-chloronicotinoyl chloride (1.67g, 9.49mmol) to give 16q (546mg, 18% from 2-chloronicotinoyl chloride) as a white solid by the method described for 18: mp 214-216C (from ethyl acetate/EtOH); 1H NMR (400MHz, CDCl3) delta 8.68 (dd, J=7.9, 1.8Hz, 1H), 8.53-8.58 (m, 1H), 8.04 (d, J=8.5Hz, 1H), 7.82 (d, J=2.0Hz, 1H), 7.63 (d, J=5.4Hz, 1H), 7.41 (d, J=5.5Hz, 1H), 7.34-7.40 (m, 1H), 7.28 (dd, J=8.5, 2.1Hz, 1H), 3.72 (s, 3H); 13C NMR (100MHz, CDCl3) delta 169.94, 165.54, 156.14, 152.66, 140.93, 140.83, 138.06, 137.53, 129.15, 124.65, 123.88, 123.42, 123.35, 123.22, 119.88, 40.94; MS (FAB) m/z 326 (M++1). Anal. Calcd for C16H11N3OS2: C, 59.06; H, 3.41; N, 12.91; S, 19.71. Found: C, 59.03; H, 3.23; N, 12.79; S, 19.48.
4965-26-8, The synthetic route of 4965-26-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Inami, Hiroshi; Shishikura, Jun-Ichi; Yasunaga, Tomoyuki; Ohno, Kazushige; Yamashita, Hiroshi; Kato, Kota; Sakamoto, Shuichi; Bioorganic and Medicinal Chemistry; vol. 23; 8; (2015); p. 1788 – 1799;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem