With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360576-01-8,Methyl 6-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
12196] A mixture of 500 mg of methyl 6-bromobenzo[b] thiophene-2-carboxylate, 458 mg of 2-trifluoromethyl-5-py- ridyl boronic acid, 407 mg of lithium chloride, 352 mg of sodium carbonate, 107 mg of tetrakis(triphenylphosphine) palladium (0), 20 ml of 1 ,4-dioxane, and 10 ml of water was stirred for 2 hours at 1000 C. After being cooled to room temperature, the reaction mixture was concentrated under reduced pressure. Chloroform was added to the residues, and insoluble matter was separated by filtration. Afier water was added to the filtrate, extraction was performed using chloroform. The organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The residues were subjected to silica gel column chromatography, thereby obtaining 366mg of methyl 6-(6-trifluoromethyl-3-pyridyl)benzo[b]thiophene-2-car- boxylate (hereinafier, described as a ?compound 49 of thepresent invention?). 12197] Compound 49 of the Present Invention12198] ?H-NMR (CDC13) oe: 9.02 (s, 1H), 8.12-8.10 (m,3H), 8.03-8.01 (m, 1H), 7.81-7.79 (m, 1H), 7.66-7.63 (m,1H), 3.98 (s, 3H)., 360576-01-8
As the paragraph descriping shows that 360576-01-8 is playing an increasingly important role.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem