Day: November 5, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.,4923-87-9

General procedure: A mixture of magnesium (288 mg, 12 mmol) and aryl bromide (15.6 mmol) was reacted in dry tetrahydrofuran under reflux for 30 minutes. Then, a solution of 2-aminobenzonitrile (708 mg, 6.0 mmol) in dry tetrahydrofuran (8 mL) was added slowly. After a refluxed period (2 h), methyl chloroformate (977 mg, 9.0 mol) was added dropwise at 0 C, and the resulting mixture was refluxed for 14 h. The mixture was cooled to ambient temperature and poured into a hydrochloric acid solution (2 M). The mixture was neutralized with 10% sodium bicarbonate aqueous solution and extracted with dichloromethane (30 mL ¡Á 3). The combined organic layer was dried over anhydrous sodium sulfate, concentrated in vacuo. The residue obtained was purified by flash column chromatography using dichloromethane/methanol as eluent to achieve the product. 4-(benzo[b]thiophen-5-yl)quinazolin-2(1H)-one (1m): white solid, mp: 312-313 C, 70% yield, the new compound, Rf = 0.25 (dichloromethane/methanol = 25/1); 1H NMR (400 MHz, DMSO-d6) delta 11.97 (s, 1H), 8.22 (d, J = 8.7 Hz, 2H), 7.91 (d, J = 5.4 Hz, 1H), 7.75 (t, J = 7.8 Hz, 2H), 7.67 (dd, J = 8.4, 1.1 Hz, 1H), 7.62 (d, J = 5.4 Hz, 1H), 7.40 (d, J = 8.1 Hz, 1H), 7.22 (t, J = 7.6 Hz, 1H). 13C NMR (100 MHz, DMSO-d6) delta 175.6, 155.4, 143.9, 141.5, 139.7, 135.6, 133.2, 129.4, 129.1, 125.5, 125.2, 125.0, 123.2, 122.9, 116.0, 114.8. HRMS (ESI) m/z Calculated for C16H10N2OS [M+H]+ 279.0587, found 279.0584.

The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Meng, Fan-Jie; Shi, Lei; Jiang, Wen-Feng; Feng, Guang-Shou; Lu, Xiao-Bing; Zhao, Zi-Biao; Tetrahedron Letters; vol. 60; 33; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.

EXAMPLE 213 5-(1-decynyl)-2-benzo[b]thiophenecarboxaldehyde To a solution of 5 (1-decynyl)benzo[b]thiophene (20.0 g) in dry ether (150 ml), under nitrogen, was added n-butyllithium (2.5M in hexanes) (32.6 ml) dropwise, with stirring at room temperature. The solution was stirred at room temperature, under nitrogen, for 2.5 hrs and then cooled to -60 C. A solution of dry dimethylformamide (5.95 g) in dry ether (15 ml) was added dropwise, and the reaction mixture was allow to warm to room temperature. The reaction mixture was quenched with ammonium chloride solution and the layers separated. The aqueous phase was extracted with ether, the organic extracts combined, dried over anhydrous sodium sulfate, filtered, and the filtrate was evaporated. The residue was flash chromatographed (silica: 3-4%, ethyl acetate:heptane). The appropriate fractions were collected and evaporated. The residue was recrystallized from heptane to give 11.5 g (52.0%) of product, mp 45-47 C. Analysis: Calculated for C19 H22 OS: 76.47%C 7.43%H Found: 76.63%C 7.36%H, 95-15-8

95-15-8 Thianaphthene 7221, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Hoechst-Roussel Pharmaceuticals Incorporated; US5360811; (1994); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 400 mg of methyl 5-aminobenzo[b]thiophene-2-carboxylate, 56 mg of lithium hydroxide monohydrate,5 ml of water, and 15 ml of methanol was stirred for 2 hours at 80C. After being cooled to room temperature, thereaction mixture was concentrated under reduced pressure. Water was added to the residues, and the residue waswashed three times with tert-butyl methyl ether. One (1) M hydrochloric acid was added to the aqueous layer to adjustpH thereof to 5 to 6. The precipitated solids were collected by filtration. The obtained solids were washed with waterand ethyl acetate and then dried under reduced pressure, thereby obtaining 280 mg of 5-aminobenzo[b]thiophene-2-carboxylic acid (hereinafter, described as a “compound 61 of the present invention”) 1H-NMR (DMSO-D6) delta: 7.82 (s, 1H), 7.63 (d, 1H, J = 8.8 Hz), 7.03 (d, 1H, J = 2.2 Hz), 6.86 (dd, 1H, J = 8.8, 2.2 Hz)., 20699-85-8

The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company Limited; MUKUMOTO, Fujio; TAMAKI, Hiroaki; KUSAKA, Shintaro; IWAKOSHI, Mitsuhiko; EP2926660; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, General procedure: As a typical experiment, the reaction of the aryl bromide (1 mmol), benzothiophene (1.5 mmol) and KOAc (0.196 g, 2 mmol) at 150C during 16 h in DMF or DMAc (4 mL) in the presence of Pd(OAc)2 (0.224 mg,0.001 mmol) or (1.12 mg, 0.005 mmol) prepared as a solution in DMAc (1 mg of Pd(OAc)2 in 1 mL of DMAc) under argon affords the coupling product after evaporation of the solvent and purificationon silica gel.

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Zhao, Liqin; Bruneau, Christian; Doucet, Henri; Tetrahedron; vol. 69; 34; (2013); p. 7082 – 7089;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

This compound was synthetized using a modified procedure of . 7-bromobenzo[b]thiophene (1.0 g, 4.69 mmol, 1.0 eq.) was dissolved in diethyl ether (25 ml) and cooled at -40C. Then n-butyllithium 1.6 M (3.23 ml, 5.16 mmol, 1.1 eq) was added dropwise and the solution was warmed to 0C over a 1 h period. The solution was cooled to -60C and a solution of 2,2,2-trifluoro-1-morpholinoethan-1-one (0.86 g, 4.69 mmol, 1.0 eq) in diethyl ether (5 ml) was added in portions. The resultant mixture was stirred at -60C for 7 h and then warmed up to room temperature. The solution was hydrolyzed with saturated NH4Cl (5 ml), washed with NH4Cl (3 x 5 ml) and water (3 x 5 ml), dried (Na2SO4) and concentrated. The resulting residue was purified by flash column chromatography on silica gel using ethyl hexane: ethyl acetate (10:1) as eluent to afford a light-yellow solid (0.98 g, 91%). 1H-NMR (300 MHz, CDCl3) delta = 8.20 (ddd, J = 7.9, 4.5, 1.4 Hz, 2H), 7.70 (d, J = 5.5 Hz, 1 H), 7.58 (t, J = 7.9 Hz, 1 H), 7.49 (d, J = 5.5 Hz, 1 H). 19F NMR (282 MHz, CDCl3) delta = – 69.54 (s, CF3)., 1423-61-6

As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.

Reference£º
Patent; Oncostellae, S.L.; KURZ, Guido; CAMACHO GOMEZ, Juan; (123 pag.)EP3480201; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Dichloro l,l ‘-bis(diphenylphosphino)ferrocene palladium(II) (14 g, 0.018 mol) was added to a mixture of 7-bromo-l-benzothiophene (Intermediate XI 3) (75 g, 0.35 mol, from Step 2), bis(pinacolato)diboron (110 g, 0.42 mol), potassium acetate (170 g, 1.8 mol), and toluene (750 mL) at room temperature under an argon atmosphere. The reaction mixture was then heated at 100 C. After 12 h, the reaction mixture was cooled to room temperature, partitioned between water and ethyl acetate, and the layers were separated. The organic material was washed sequentially with water and brine, dried (sodium sulfate), filtered, and the filtrate was concentrated under a vacuum. The residue was subjected to flash chromatography on silica gel (99: 1 hexane-ethyl acetate) to give 2-(l-benzothiophen-7-yl)-4,4,5,5-tetramethyl-l,3,2-dioxaborolane (60 g, Intermediate Y2) as a colorless solid, 1423-61-6

As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael D.; BOURBEAU, Matthew Paul; CROGHAN, Michael D.; FOTSCH, Christopher H.; HUNGATE, Randall W.; KONG, Ke; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis D.; REICHELT, Andreas; SIEGMUND, Aaron C.; TADESSE, Seifu; ST. JEAN, David Jr; YANG, Kevin C.; YAO, Guomin; WO2013/173382; (2013); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, Thianaphthene-3-carboxaldehyde (1.62 g, 10.0 mmol) was dissolved in anhydrous ethanol (50 mL). Sulfamide (4.0 g, 42 mmol) was added and the mixture was heated to reflux for 16 hours. The mixture was cooled to room temperature. Sodium borohydride (0.416 g, 11.0 mmol) was added and the mixture was stirred at room temperature for three hours. The reaction was diluted with water (50 mL) and extracted with chloroform (3¡Á75 mL). The extracts were concentrated and chromatographed (5% methanol in DCM) to yield the title compound as a white solid.1H NMR (DMSO-d6): delta 7.98 (1H, dd, J=6.5, 2.3 Hz), 7.92 (1H, dd, J=6.6, 2.4 Hz), 7.62 (1H, s), 7.36-7.45 (2H, m), 7.08 (1H, t, J=6.3 Hz), 6.72 (2H, s), 4.31 (2H, d, J=6.3 Hz).

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Smith-Swintosky, Virginia L.; US2007/191451; (2007); A1;; ; Patent; Smith-Swintosky, Virginia L.; US2007/191453; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10133-22-9,5-(Bromomethyl)benzo[b]thiophene,as a common compound, the synthetic route is as follows.

First method A solution of 8.6 g (0.0506 mole) of 1-(2-thiazolyl) piperazine and 5.75 g (0.0253 mole) of 5-bromomethyl benzo [b ] thiophene (MP 37 C) in 145 ml of anhydrous toluene containing 5 ml of dimethylformamide was stirred at 25 for 24 hours. At the completion of the reaction, the thiazolyl piperazine hydrobromide which had formed was filtered off and the solvent was evaporated from the filtrate under reduced pressure. There were obtained 10 g of a yellow oil which was treated with 50 ml of a 2N hydrochloric acid solution. The acid solution was washed with ether and the base was salted out with an excess of potassium carbonate. There were obtained 6 g of a crude crystallized product, which was recrystallized in 20 ml of ethanol to give 5 g of 1-(5-benzo [b] thienylmethyl)-4-(2-thiazolyl) piperazine as beige crystals melting at 80-82 C., 10133-22-9

The synthetic route of 10133-22-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Science-Union et Cie; US3954765; (1976); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4965-26-8,5-Nitrobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

5-Nitro-1-benzothiophene (1.70g, 9.49mmol) was hydrogenated in ethanol (34ml) under 3atm of H2 in the presence of 5% Pd/C (0.17g). After removal of the catalyst by filtration, the filtrate was concentrated in vacuo to give an amino derivative. This compound was methylated using the procedure described by Crochet et al.41 The crude product thus obtained was treated with 2-chloronicotinoyl isothiocyanate (9) prepared from 2-chloronicotinoyl chloride (1.67g, 9.49mmol) to give 16q (546mg, 18% from 2-chloronicotinoyl chloride) as a white solid by the method described for 18: mp 214-216C (from ethyl acetate/EtOH); 1H NMR (400MHz, CDCl3) delta 8.68 (dd, J=7.9, 1.8Hz, 1H), 8.53-8.58 (m, 1H), 8.04 (d, J=8.5Hz, 1H), 7.82 (d, J=2.0Hz, 1H), 7.63 (d, J=5.4Hz, 1H), 7.41 (d, J=5.5Hz, 1H), 7.34-7.40 (m, 1H), 7.28 (dd, J=8.5, 2.1Hz, 1H), 3.72 (s, 3H); 13C NMR (100MHz, CDCl3) delta 169.94, 165.54, 156.14, 152.66, 140.93, 140.83, 138.06, 137.53, 129.15, 124.65, 123.88, 123.42, 123.35, 123.22, 119.88, 40.94; MS (FAB) m/z 326 (M++1). Anal. Calcd for C16H11N3OS2: C, 59.06; H, 3.41; N, 12.91; S, 19.71. Found: C, 59.03; H, 3.23; N, 12.79; S, 19.48.

4965-26-8, The synthetic route of 4965-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Inami, Hiroshi; Shishikura, Jun-Ichi; Yasunaga, Tomoyuki; Ohno, Kazushige; Yamashita, Hiroshi; Kato, Kota; Sakamoto, Shuichi; Bioorganic and Medicinal Chemistry; vol. 23; 8; (2015); p. 1788 – 1799;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360576-01-8,Methyl 6-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

12196] A mixture of 500 mg of methyl 6-bromobenzo[b] thiophene-2-carboxylate, 458 mg of 2-trifluoromethyl-5-py- ridyl boronic acid, 407 mg of lithium chloride, 352 mg of sodium carbonate, 107 mg of tetrakis(triphenylphosphine) palladium (0), 20 ml of 1 ,4-dioxane, and 10 ml of water was stirred for 2 hours at 1000 C. After being cooled to room temperature, the reaction mixture was concentrated under reduced pressure. Chloroform was added to the residues, and insoluble matter was separated by filtration. Afier water was added to the filtrate, extraction was performed using chloroform. The organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The residues were subjected to silica gel column chromatography, thereby obtaining 366mg of methyl 6-(6-trifluoromethyl-3-pyridyl)benzo[b]thiophene-2-car- boxylate (hereinafier, described as a ?compound 49 of thepresent invention?). 12197] Compound 49 of the Present Invention12198] ?H-NMR (CDC13) oe: 9.02 (s, 1H), 8.12-8.10 (m,3H), 8.03-8.01 (m, 1H), 7.81-7.79 (m, 1H), 7.66-7.63 (m,1H), 3.98 (s, 3H)., 360576-01-8

As the paragraph descriping shows that 360576-01-8 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem