Downstream synthetic route of 1127-35-1

The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

A mixture of benzo[b]thiophen-3(2H)-one-1,1-dioxide (1b)(0.77 g, 4.2 mmol), paraformaldehyde (0.08 g, 2.5 mmol) and ammonium acetate(0.69 g, 9.0 mmol) in a mixture of toluene (30 mL) and acetic acid (5 mL) washeated at azeotropic reflux condition with the removal of water for 3 h. Aftercooling a white precipitate was ltered off and crystallised from acetic acidgiving 2b (0.65 g, 78%). The 1HNMR spectrum was in accordance with the one described above for the compound 2b., 1127-35-1

The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cekavicus, Brigita; Vigante, Brigita; Rucins, Martins; Plotniece, Aiva; Pajuste, Karlis; Petrova, Marina; Belyakov, Sergey; Duburs, Gunars; Sobolev, Arkadij; Tetrahedron Letters; vol. 55; 33; (2014); p. 4601 – 4604;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem