With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.
A mixture of benzo[b]thiophen-3(2H)-one-1,1-dioxide (1b)(0.77 g, 4.2 mmol), paraformaldehyde (0.08 g, 2.5 mmol) and ammonium acetate(0.69 g, 9.0 mmol) in a mixture of toluene (30 mL) and acetic acid (5 mL) washeated at azeotropic reflux condition with the removal of water for 3 h. Aftercooling a white precipitate was ltered off and crystallised from acetic acidgiving 2b (0.65 g, 78%). The 1HNMR spectrum was in accordance with the one described above for the compound 2b., 1127-35-1
The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Cekavicus, Brigita; Vigante, Brigita; Rucins, Martins; Plotniece, Aiva; Pajuste, Karlis; Petrova, Marina; Belyakov, Sergey; Duburs, Gunars; Sobolev, Arkadij; Tetrahedron Letters; vol. 55; 33; (2014); p. 4601 – 4604;,
Benzothiophene – Wikipedia
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