3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A solution of saturated aqueous ammonium chloride (10 mL)was added dropwise with stirring to a suspension of heteroaryl-2-carbaldehyde (10 mmol), propargyl bromide (80% in toluene,2.23 g, 15 mmol) and zinc dust (3.27 g, 50 mmol) in THF(20 mL) at 0 C (ice bath) over 1 h. The mixture was allowed towarm to room temperature and was stirred at this temperaturefor 24 h, with monitoring by TLC. The mixture was filtered andthe filter cake was washed with ethyl acetate (5 100 mL). Thecombined filtrates were washed with saturated aqueousammonium chloride (50 mL), then brine (50 mL) and dried overmagnesium sulfate. The residue was purified by flash chromatographyon silica gel to afford homopropargylic alcohol as an oilyproduct. 4.2.1 rac-1-(Benzo[b]thiophen-2-yl)but-3-yn-1-ol 1a Light yellow oil (1.54 g, 76% yield); Rf: 0.3 (1:5 EtOAc/hexane); 1H NMR (CDCl3, 400 MHz): delta 7.83-7.81 (m, 1H), 7.75-7.72 (m, 1H), 7.37-7.29 (m, 2H), 7.27-7.26 (m, 1H), 5.22-5.17 (m, 1H), 2.84-2.82 (m, 2H), 2.62 (d, J = 4.7 Hz, 1H), 2.13 (t, J = 2.7 Hz, 1H); 13C NMR (CDCl3, 400 MHz): delta 146.6, 139.3, 124.4, 123.6, 122.5, 120.7, 79.7, 71.8, 69.0, 29.3.
3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Article; Bueyuekadali, Nalan Nuriye; Seven, Semih; Aslan, Nezir; Yenidede, Duygu; Guemue, Ayeguel; Tetrahedron Asymmetry; vol. 26; 21-22; (2015); p. 1285 – 1291;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem