With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.
General procedure: Amine (1.5 eq.) and appropriate aldehyde (1 eq.) were dissolved in MeOH/CH2Cl2 mixture(2:1 v:v), AcOH glac (1.5 eq.) was added, and the mixture was stirred under an Ar atmosphere at r.t.After 3 h, NaBH4 (6 eq.) was added, and stirring was continued for another 18 h. Solvent was removedunder reduced pressure, and the residue was dissolved in CH2Cl2. The organic layer was washed with2M NH4OH, water and then extracted with CH2Cl2. The combined organic layers were washed withbrine and dried over anhydrous Na2SO4. Finally, the solvent was evaporated under reduced pressure., 3541-37-5
The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Konstantinovi?, Jelena; Videnovi?, Milica; Srbljanovi?, Jelena; Djurkovi?-Djakovi?, Olgica; Bogojevi?, Katarina; Sciotti, Richard; ?olaja, Bogdan; Molecules; vol. 22; 3; (2017);,
Benzothiophene – Wikipedia
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