Day: November 3, 2020

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of saturated aqueous ammonium chloride (10 mL)was added dropwise with stirring to a suspension of heteroaryl-2-carbaldehyde (10 mmol), propargyl bromide (80% in toluene,2.23 g, 15 mmol) and zinc dust (3.27 g, 50 mmol) in THF(20 mL) at 0 C (ice bath) over 1 h. The mixture was allowed towarm to room temperature and was stirred at this temperaturefor 24 h, with monitoring by TLC. The mixture was filtered andthe filter cake was washed with ethyl acetate (5 100 mL). Thecombined filtrates were washed with saturated aqueousammonium chloride (50 mL), then brine (50 mL) and dried overmagnesium sulfate. The residue was purified by flash chromatographyon silica gel to afford homopropargylic alcohol as an oilyproduct. 4.2.1 rac-1-(Benzo[b]thiophen-2-yl)but-3-yn-1-ol 1a Light yellow oil (1.54 g, 76% yield); Rf: 0.3 (1:5 EtOAc/hexane); 1H NMR (CDCl3, 400 MHz): delta 7.83-7.81 (m, 1H), 7.75-7.72 (m, 1H), 7.37-7.29 (m, 2H), 7.27-7.26 (m, 1H), 5.22-5.17 (m, 1H), 2.84-2.82 (m, 2H), 2.62 (d, J = 4.7 Hz, 1H), 2.13 (t, J = 2.7 Hz, 1H); 13C NMR (CDCl3, 400 MHz): delta 146.6, 139.3, 124.4, 123.6, 122.5, 120.7, 79.7, 71.8, 69.0, 29.3.

3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Bueyuekadali, Nalan Nuriye; Seven, Semih; Aslan, Nezir; Yenidede, Duygu; Guemue, Ayeguel; Tetrahedron Asymmetry; vol. 26; 21-22; (2015); p. 1285 – 1291;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a flask containing 4.1mmol of a selected aromatic aldehyde in 10.2mL of methanol at 0C were added 0.7452g (5.4mmol) of tyramine. The solution was allowed to stir for 45min and 0.1808g (4.8mmol) of sodium borohydride was added. The solution was allowed to stir for 4.5h, at which point 0.1679g (4.4mmol) of additional sodium borohydride was added. This mixture was stirred overnight and the formed precipitate was collected via vacuum filtration. No further purification was required at this stage. The NMR spectral data for known compounds (2a [51], 2b [50], and 2e [50]) matched those in the literature. The characterization of all new compounds is given below., 5381-20-4

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Henry, Sean; Kidner, Ria; Reisenauer, Mary R.; Magedov, Igor V.; Kiss, Robert; Mathieu, Veronique; Lefranc, Florence; Dasari, Ramesh; Evidente, Antonio; Yu, Xiaojie; Ma, Xiuye; Pertsemlidis, Alexander; Cencic, Regina; Pelletier, Jerry; Cavazos, David A.; Brenner, Andrew J.; Aksenov, Alexander V.; Rogelj, Snezna; Kornienko, Alexander; Frolova, Liliya V.; European Journal of Medicinal Chemistry; vol. 120; (2016); p. 313 – 328;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

A. Preparation of nitrobenzo[b]thiophene-3-carboxaldehydes. A solution of 9 g of benzo[b]thiophene-3-carboxaldehyde in 50 ml of acetic anhydride was cooled to 0 C. by means of an external ethanol/ice bath. A solution of 40 ml of acetic acid and 20 ml of fuming nitric acid was added at such a rate to maintain the temperature of the reaction at 0-5 C. Following the addition of the reagents, the reaction mixture was stirred for 1.5 hours. The reaction mixture was poured into 500 ml of ice and extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate, and evaporated in vacuo. The resulting oil was treated with ethanol. A solid formed, which was recovered by filtration providing 1.3 g of 6-nitrobenzo[b]thiophene-3-carboxaldehyde, m.p. 187-192 C. The ethanol filtrate was evaporated providing an oil which was purified by chromatography over silica gel eluding with cyclohexane.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eli Lilly and Company; US4659717; (1987); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22720-75-8,2-Acetylbenzothiophene,as a common compound, the synthetic route is as follows.

To a solution of compound 1 (1.76 g, 12 mmol) and compound 2 (1.76 g, 10 mmol) dissolved in ethanol (20 ml) was added an aqueous solution of potassium hydroxide (1.12 g, 20 mmol) (1.1 ml). The mixture was stirred at room temperature overnight, and water was added to the mixture and precipitates were collected by filtration. The pre- cipitates were washed with water, dissolved in ethyl acetate-THF, and dried over anhydrous magnesium sulfate. Activated charcoal was added to the extract, and the mixture was filtered and the filtrate was concentrated. The residue was triturated from ethyl acetate-isopropyl ether to give compound 3 (2.36 g, [77 percent).] MS-APCI (m/z): 305/307 [([M+H] +)]

22720-75-8, 22720-75-8 2-Acetylbenzothiophene 89805, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Tanabe Seiyaku Co., Ltd.; WO2004/35570; (2004); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Amine (1.5 eq.) and appropriate aldehyde (1 eq.) were dissolved in MeOH/CH2Cl2 mixture(2:1 v:v), AcOH glac (1.5 eq.) was added, and the mixture was stirred under an Ar atmosphere at r.t.After 3 h, NaBH4 (6 eq.) was added, and stirring was continued for another 18 h. Solvent was removedunder reduced pressure, and the residue was dissolved in CH2Cl2. The organic layer was washed with2M NH4OH, water and then extracted with CH2Cl2. The combined organic layers were washed withbrine and dried over anhydrous Na2SO4. Finally, the solvent was evaporated under reduced pressure., 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Konstantinovi?, Jelena; Videnovi?, Milica; Srbljanovi?, Jelena; Djurkovi?-Djakovi?, Olgica; Bogojevi?, Katarina; Sciotti, Richard; ?olaja, Bogdan; Molecules; vol. 22; 3; (2017);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1423-61-6, A solution OF 7-BROMO-1-BENZOTHIOPHENE (19.9 g, 0.094 mol) in absolute ether (200 ml) was treated with a 1.6 M solution of n-butyllithium in hexane (0.14 mol, 88 ml) AT-78 C. The solution was stirred at-78 C for 10 minutes then treated with trimethyl borate (15 ml, 0.14 mol). The mixture was allowed to warm to-10 C then quenched with an excess of dilute hydrochloric acid. The organic layer was separated, dried, evaporated, and the residue was recrystallised from aqueous ethanol to yield the title compound (10 g, 60%).

The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck Sharp & Dohme Limited; WO2004/46133; (2004); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0055] Calixarene 7 (benzothiophene-pyrogallol calix[4]arene) was prepared by the following method. To a 250 mL round bottom flask, pyrogallol (1,2,3-trihydroxybenzene, 3.89 g, 30.8 mmol), benzo[b]thiophene-2-carboxaldehyde (5.00 g, 30 8 mmol), ethanol (100 mL), and HCl (concentrated, 10 mL) were added. A nitrogen inlet was equipped and the reaction was stirred at 80 C. for 16 hours. The reaction began as a clear solution but slowly formed a purple precipitate. After completion of the reaction, the resulting solution was filtered through a fritted funnel and the solid was washed with water (50 mL) and ethanol (50 mL). The product was dried in vacuo at 60 C. for 16 hours (yield: 6.30 g, 76%). LC-MS m/z=1081.2 g/mol

3541-37-5, The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ROHM AND HAAS ELECTRONIC MATERIALS LLC; Green, D. Patrick; Jain, Vipul; Bailey, Brad C.; US2013/157195; (2013); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, General procedure: A 100-mL, round-bottom flask equipped with a magnetic stirring bar was charged with TZD (1 mmole) and rhodanine(1 mmol) in ionic liquid ChCl/urea was added aldehyde (1mmol). The reaction mixture was stirred for adequate amount of time under solvent-free conditions (Table 2). The progress of the reaction was monitored by TLC(Chloroform: Methanol (4:1). After completion of the reaction, H2O (3 ml) was added and ILs separated. Then, the obtained crude compound was collected by filtration and then washed with water and methanol. Finally, products were recrystallized from ethanol to afford (1-10) a, b in the excellent yield.

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Akhavan, Malihe; Bekhradnia, Ahmadreza; Foroughifar, Naser; Pasdar, Hoda; Combinatorial chemistry and high throughput screening; vol. 22; 10; (2019); p. 716 – 727;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Benzo[b]thiophen-3-ylmethyl-[2-(1-methyl-pyrrolidin-2-yl)-ethyl]-amine Experimental condition analogous to Example 5, from benzo[b]thiophen-3-carbaldehyde 0.16 g (1 mmol), 2-(1-methyl-pyrrolidin-2-yl)-ethylamine 0.14 g (1.1 mmol), and sodium triacethoxyborohydride 0.31 g (1.5 mmol), in 10 mL Dichloromethane. Purification using silica chromatography, elution with dichloromethane-methanol-ammonium hydroxide, 9-1-0.25, gave 140 mg of compound., 5381-20-4

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; ChemoCentryx, Inc.; US2006/74071; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.

95-15-8, Benzothiophene is n- butyl lithium and reaction of the intermediate obtained after the homo coupling reaction proceeds M63-1 (homocoupling reaction) under the action of anhydrous yeomhwadong After obtaining the lithium salt through a NBS bromination homo bromide M63-2 after getting the n- butyl lithium and reaction to obtain a pair bromide M63-4 through the NBS bromination and then generate a lithium salt, and the intermediate obtained through the homo-coupled anti-M63-3 under the action of anhydrous methyl N- yeomhwadong to give a compound of boric acid and 3-M63 via a Suzuki coupling reaction (white solid, yield 53%).

The synthetic route of 95-15-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kunshan visionox Display Company Limited; Beijing Dingchai Technology Company Limited; Beijing visionox Technology Company Limited; Tsinghua University; Chiu, Yong; Pan, Hong Tao; Wang, Sing; Duan, Leanne; Run, Syueien; (77 pag.)KR2015/65184; (2015); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem