With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
5381-20-4, A mixture of 2-aminohistamine (0.11 mmol) and 3-benzothiophene carboxaldehyde (0.13 mmol) was stirred in ethanol at room temperature for 6 h, after which 10% PdVC (24 mg) was added and the reaction mixture refluxed for a further 24 h. The mixture was then filtered through a celite pad, washed with ethanol (3 x 25 mL) and5 toluene (2 x 20 mL). The combined filtrates were concentrated under reduced pressure and chromatographed over silica gel using a gradient of 5:95 – 20:80 giving pure 4- (benzothiophen-3-yl)-lH-imidazo[4,5-c]pyridin-2-amine (22.2 mg; 76%) as a white solid. 1H NMR (400 MHz, CD3OD) delta 8.29 (s, IH), 8.27 (d, J = 6.5 Hz, IH), 8.10-8.07 (m, IH), 7.79-7.75 (m, IH), 7.60 (d, J= 6.5 Hz, IH), 7.55-7.48 (m, 2H). 0
The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MACQUARIE UNIVERSITY; WO2009/152584; (2009); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem