Analyzing the synthesis route of 360576-01-8

360576-01-8, As the paragraph descriping shows that 360576-01-8 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360576-01-8,Methyl 6-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

12144] A mixture of 900 mg of methyl 6-bromobenzo[b] thiophene-2-carboxylate, 2.28 ml of diisopropylamine, 116 mg of dichlorobis(triphenylphosphine)palladium (II), 32mg of copper iodide (1), 0.92 ml of trimethylsilyl acetylene, and 15 ml of toluene was stirred for 20 hours at room temperature under a nitrogen atmosphere. The reaction mixture was concentrated under reduced pressure, hexane was added to the residues, and insoluble matter was separated by filtration. The filtrate was concentrated under reduced pressure, and the residues were subjected to silica gel colunm chromatography, thereby obtaining 590mg ofmethyl 6-(trimethylsilylethynyl) benzo[b]thiophene-2-carboxylate.

360576-01-8, As the paragraph descriping shows that 360576-01-8 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
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