Month: November 2020

5394-13-8, In an article, published in an article,authors is Chen, Huoji, once mentioned the application of 5394-13-8, Name is 2-Bromobenzo[b]thiophene,molecular formula is C8H5BrS, is a conventional compound. this article was the specific content is as follows.

Palladium-catalyzed regioselective azidation of allylic C-H bonds under atmospheric pressure of dioxygen

A palladium-catalyzed allylic azidation of alkenes with sodium azide under atmospheric pressure of dioxygen was developed. This methodology provides a new efficient and simple route for accessing allylic azides. Furthermore, the one-pot process consisting of Pd-catalyzed allylic azidation of alkenes and Cu-catalyzed 1,3-dipolar cycloaddition led directly to the 1,2,3-triazole from the alkene. The formed allylic azide can be also in situ reduced to the allylic amine or oxidized to the alkenyl nitrile. the Partner Organisations 2014.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 35212-85-2, molcular formula is C10H9NO2S, introducing its new discovery. , 35212-85-2

CONDENSED COMPOUND AND ORGANIC LIGHT EMITTING DEVICE INCLUDING THE SAME

Disclosed is a novel condensed cyclic compound and an organic light emitting device including the same.COPYRIGHT KIPO 2015

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 35212-85-2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 35212-85-2

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

26018-73-5, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 26018-73-5, molcular formula is C9H5ClO2S, introducing its new discovery.

SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) BENZOHETEROARYL COMPOUNDS

This invention is directed to an (aminoiminomethyl or aminomethyl) benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 26018-73-5, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 26018-73-5

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.66490-33-3, Name is 4-Chlorobenzo[b]thiophene, molecular formula is C8H5ClS, 66490-33-3. In a Article, authors is Takeuchi, Kumiko£¬once mentioned of 66490-33-3

Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1

A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. 1-(1H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high affinity at the 5-HT1A receptor and serotonin reuptake inhibition at nanomolar concentrations for dual activities.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.66490-33-3. In my other articles, you can also check out more blogs about 66490-33-3

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

20532-28-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 20532-28-9, Name is 5-Aminobenzothiophene, molecular formula is C8H7NS. In a Article, authors is Murakami, Yasushi£¬once mentioned of 20532-28-9

1,3-Disubstituted benzazepines as novel, potent, selective neuropeptide Y Y1 receptor antagonists

A novel series of potent and selective non-peptide neuropeptide Y (NPY) Y1 receptor antagonists, having benzazepine nuclei, have been designed, synthesized, and evaluated for activity. Chemical modification of the R1 and R3 substituents in structure 1 (Chart 1) yields several compounds that show high affinity for the Y1 receptor (K(i) values of less than 10 nM). SAR studies revealed that introduction of an isopropylurea group at R1 and a 3- (benzo-condensed-urea) group, 3-(fluorophenylurea) group, or a 3-(N-(4- hydroxyphenyl)guanidine) group at R3 in structure 1 afforded potent and subtype-selective NPY Y1 receptor antagonists. 3-(3-(Benzothiazol-6- yl)ureido)-1-N-(3-(N’-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1- benzazepin-2-one (21), which was one of the most potent derivatives, competitively inhibited specific [125I]peptide YY (PYY) binding to Y1 receptors in human neuroblastoma SK-N-MC cells (K(i) = 5.1 nM). 21 not only inhibited the Y1 receptor-mediated increase in cytosolic free Ca2+ concentration in SK-N-MC cells but also antagonized the Y1 receptor-mediated inhibitory effect of peptide YY on gastrin-induced histamine release in rat enterochromaffin-like cells. 21 showed no significant affinity in 17 receptor binding assays including Y2, Y4, and Y5 receptors.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 20532-28-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 20532-28-9, in my other articles.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

4923-87-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4923-87-9, Name is 5-Bromobenzothiophene, molecular formula is C8H5BrS. In a Article, authors is Rocco, Vincent P.£¬once mentioned of 4923-87-9

Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3- piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4

A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective of the regiochemistry associated with its connectivity to the piperidine central ring.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4923-87-9

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

19301-35-0, An article , which mentions 19301-35-0, molecular formula is C8H6OS. The compound – Benzo[b]thiophen-5-ol played an important role in people’s production and life.

Palladium-catalyzed hydroxylation of aryl and heteroaryl halides enabled by the use of a palladacycle precatalyst

A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 5394-13-8, molecular formula is C8H5BrS, introducing its new discovery. 5394-13-8

2,2′-thienylbenzothiophenes, their preparation and their use for controlling pests

2,2′-Thienylbenzothiophenes of the general formula I STR1 where R1 and R3 independently of one another are each halogen, alkyl, haloalkyl, alkoxy or haloalkoxy, R2 is hydrogen, halogen, alkyl, haloalkyl, alkoxy or haloalkoxy, n is 0, 1 or 2, and the radicals may be different when n is 2, and m is 0, 1, 2, 3 or 4, and the radicals may be different when m is 2, 3 or 4, processes for their preparation, pesticides containing them and the use thereof.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

35212-85-2, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 35212-85-2, molecular formula is C10H9NO2S, introducing its new discovery.

Novel hetero-cyclic compound and organic light emitting device comprising the same

The present invention refers to novel heterocyclic compound and organic light emitting number including […] substrate. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.35212-85-2, you can also check out more blogs about35212-85-2

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

63675-74-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Goulielmaki, Maria and a compound is mentioned, 63675-74-1, 6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophene, introducing its new discovery.

DPS-2: A Novel Dual MEK/ERK and PI3K/AKT Pathway Inhibitor with Powerful Ex Vivo and In Vivo Anticancer Properties

Development of novel bioactive compounds against KRAS and/or BRAF mutant colorectal cancer (CRC)is currently an urgent need in oncology. In addition, single or multitarget kinase inhibitors against MEK/ERK and PI3K/AKT pathways are of potential therapeutic advantage. A new compound based on the benzothiophene nucleus was synthesized, based on previous important outcomes on other pharmaceutical preparations, to be tested as potential anticancer agent. Treatments by 2-5 muM DPS-2 of several CRC and melanoma cell lines bearing either BRAF or KRAS mutations have shown a remarkable effect on cell viability in 2D and 3D cultures. More detailed analysis has shown that DPS-2 can kill cancer cells by apoptosis, reducing at the same time their autophagy properties. After testing activities of several signaling pathways, the compound was found to have a dual inhibition of two major proliferative/survival pathways, MEK/ERK and PI3K/AKT, in both CRC and melanoma, thus providing a mechanistic evidence for its potent anticancer activity. Antitumor activity of DPS-2 was further validated in vivo, as DPS-2 treatment of mouse xenografts of Colo-205 colorectal cancer cells remarkably reduced their tumor formation properties. Our findings suggest that DPS-2 has significant anti-KRAS/ anti-BRAF mutant CRC activity in preclinical models, potentially providing a novel treatment strategy for these difficult-to-treat tumors, which needs to be further exploited.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem