With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.
Benzo[b]thiophen-3(2H)-one 1,1-dioxide (BTD) (1mmol) and aldehyde2a-2d (1 mmol) were dissolved in 3 mL ethanol and refluxed for4-5 h. The progress of the reactionwas monitored by TLC. After completion,the reaction mass was cooled and filtered. The product obtainedwas crystallized from hot absolute ethanol (Scheme 1).2.2.1.1. 2-(Dibenzo[b,d]Furan-2-Ylmethylene)Benzo[b]Thiophen-3(2H)-One1,1-Dioxide (3a). Yellow solid, Yield: 68%, Melting point: 240-242 C, IR(KBr Pellet) cm-1 3371.57, 3095.75, 3068.75, 3020.53, 2900.94,2767.85, 2443.81, 2100.48, 1818.87, 1693.5, 1589.34, 1475.54, 1357.89,1288.45, 1193.94, 1161.15, 1056.99, 943.19, 879.54, 840.96, 808.17,746.45, 678.94, 609.51, 569, 534.28, 420.48. 1H NMR (500 MHz, CDCl3):delta 8.81 (d, J = 1.9 Hz, 1H), 8.27 (d, J = 2.0 Hz, 1H), 8.25 (s, 1H), 8.15 (d,J = 7.7 Hz, 1H), 8.10 (dd, J = 11.9, 7.7 Hz, 2H), 7.96 (t, J = 7.5 Hz, 1H),7.87 (t, J = 7.5 Hz, 1H), 7.74 (d, J = 8.6 Hz, 1H), 7.63 (d, J = 8.2 Hz,1H), 7.55 (t, J = 7.1 Hz, 1H), 7.44 (t, J = 7.5 Hz, 1H). 13C NMR(125 MHz, CDCl3): delta 178.85, 159.28, 156.94, 145.49, 144.29, 136.49,134.15, 133.37, 132.46, 129.61, 128.41, 126.94, 125.76, 125.59, 124.85,123.70, 123.17, 121.47, 121.34, 112.89, 112.00. CHN Analysis- Found: C,69.97; H, 4.36%;molecular formula C21H12O4S requires C, 69.99; H, 4.36%.
1127-35-1, 1127-35-1 Benzo[b]thiophene-3(2H)-one 1,1-Dioxide 70780, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Article; Bhagwat, Archana A.; Mohbiya, Dhanraj R.; Avhad, Kiran C.; Sekar, Nagaiyan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 203; (2018); p. 244 – 257;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem