95-15-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.
To 30 g (0.224 mol) of benzothiophene was added 500 mL of THF. After cooling to -78 C, 98.3 mL (0.246 mol) of n-BuLi 2.5M solution was slowly added dropwise. After stirring for 1 hour, 14.4 g (0.447 mol) of sulfur was added to the reaction solution. The temperature was slowly raised to room temperature, and the mixture was stirred for 12 hours and then 300 mL of 12N HCl aqueous solution was added to terminate the reaction. Separated and washed with distilled water and brine. The obtained organic layer was dried over anhydrous MgSO4, distilled under reduced pressure, and then purified by silica gel column chromatography to obtain the desired compound (25.3 g, yield 68%).
As the paragraph descriping shows that 95-15-8 is playing an increasingly important role.
Reference£º
Patent; Doosan Corporation; Sim, Jae Uii; Son, Hyo Suk; Lee, Jae Hun; Park, Ho Chul; Lee, Chang Jun; Sin, Jin Yong; Baek, Young Mi; (21 pag.)KR2015/27443; (2015); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem