Day: October 29, 2020

5381-25-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-25-9,1-Benzothiophene-3-carboxylic acid,as a common compound, the synthetic route is as follows.

Benzothiophene-3-carboxylate 2h (eq. 1, 0.624mmol) and SOCl2 (1.5 eq, 0.936mmol) in toluene was heated at reflux for 2h.The reaction was detected by TLC. After the reaction was completed, the reaction mixture was concentrated under reduced pressure to give benzo[b]thiophene-3-carbonyl chloride as a crude product.This was dissolved in 5 mL of dichloromethane, and aqueous ammonia (25% aqueous ammonia solution, 1 mL) was added dropwise thereto under ice-cooling, and stirred at room temperature.The reaction was detected by TLC. After the reaction was completed, it was washed with dilute hydrochloric acid, and then extracted with ethyl acetate (3¡Á30 mL), and then washed with saturated brine and dried over anhydrous sodium sulfate.Concentration and purification with a mobile phase of petroleum ether and ethyl acetate (V/V = 2 / 1) over silica gel column to afford white solid benzo[b]thiophene-3-carboxamide 4h as 99.5mg.4h (1 equivalent, 0.562 mmol) of benzo[b]thiophene-3-carboxamide was dissolved in 5 mL of anhydrous THF, and LiAlH4 (3 eq., 1.686 mmol) was added portionwise in an ice bath, and the mixture was refluxed for 4 hours. .After the reaction was completed, the reaction was quenched by sequentially adding 0.4 mL of H 2 O, 0.4 mL of 15% NaOH solution, and 1.2 mL of H 2 O.Ethyl acetate was added, the suspension was filtered, and the filtrate was dried over anhydrous sodium sulfate, and then the solvent was evaporated under vacuo to give benzo[b]thiophen-3-ylmethylamine as a crude product.

As the paragraph descriping shows that 5381-25-9 is playing an increasingly important role.

Reference£º
Patent; Wuhan University; Wu Shuwen; Zhou Haibing; Lan Ke; Yu Yongshi; (21 pag.)CN108129454; (2018); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

20532-33-6, 5-Chlorobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[000541j To a solution of Compound 41A (500 mg, 2.97 mmol) in THF (30 mL) was added n-BuLi (1.42 ml, 3.56 mmol) at -78 C under the protection of nitrogen. Then it was stirred at -78 C for 1 h, DMF (434 mg, 5.94 mmol) was added to the mixture and stirred for another one hour at -78 C. The reaction was quenched with sat. NH4C1. After separation, the organic phase was washed with brine, and dried over anhydrous Na2SO4, and purified by silica gel column chromatography (ethyl acetate in petroleum 20% v/v) to render Compound 41B. ?H-NMR (CDC13, 400 MHz) major characteristic peaks: (5(ppm) 7.47 (dd, J= 2.0, 8.8 Hz, 1H), 7.83 (d,J= 8.8 Hz, 1H), 7.93(d,J= 2.0 Hz, 1H), 7.97 (s, 1H), 10.11 (s, 1H)., 20532-33-6

As the paragraph descriping shows that 20532-33-6 is playing an increasingly important role.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; WO2015/65937; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.,6314-28-9

(+/-)-fralphan5-l-(Benzo[b]thiophene-2-carbonyl)-2-methyl-l,2,3,4-tetrahydro-quinoline-4- carboxylic acid (4-chloro-phenyl)-ethyl-amide was made following general procedure A, substituting benzo[b]thiophene-2-carbonyl chloride for 4-trifluoromethyl-benzoyl chlorided. Benzo[b]thiophene-2-carbonyl chloride was prepared by reaction of thianaphthene-2-carboxylic acid with oxalyl chloride and dimethylformamide in methylene chloride. The crude l-(benzo[b]thiophene-2-carbonyl)-2- methyl-l,2,3,4-tetrahydro-quinoline-4-carboxylic acid (4-chloro-phenyl)-ethyl-amide was isolated as a mixture of cis and trans isomers. Purification by silica gel chromatography (1% methanol / methylene chloride) followed by purification via HPLC yielded (+/-)-/rans-2-methyl-l-(pyrimidine-5- carbonyl)-l,2,3,4-tetrahydro-quinoline-4-carboxylic acid (4-chloro-phenyl)-ethyl-amide (34%). 1H-NMR (CDCl3) delta: 1.02 – 1.18 (m, 6H), 1.65 – 1.75 (m, IH), 2.55 – 2.65 (m, IH), 3.60 – 3.70 (m, IH),3.80 (q, 2H), 5.05 – 5.15 (m, IH), 6.70 (d, IH), 6.80 – 7.00 (m, 3H), 7.20 -7.40 (m, 4H), 7.45 (s, IH),7.50 (d, 2H), 7.70 (d, IH), 7.80 (d, IH). MS m/z: 489/491 (M+l).

6314-28-9 Benzo[b]thiophene-2-carboxylic acid 95864, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2006/91674; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22913-24-2,Methyl benzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

fac-(NEt4)2[ReBr3(CO)3] (100 mg,0.130 mmol) was dissolved in methanol (10 ml). BSOC(24.98 mg, 0.130 mmol) was added as a solid and the resultingmixture was stirred at room temperature for 2 h. The productwas collected dried in vacuo (yield: 55 mg, 0.101 mmol, 78%).IR (KBr, cm-1): nuCO 2005, 1867. UV-Vis: 211 nm, epsilon=2981 M1 cm1. 1H NMR (300 MHz, methanol-d4): delta 8.14 (s,1H), 8.02 (m, 2H), 7.51 (m, 2H), 3.92 (s, 3H). 13C NMR(150 MHz, methanol-d4): delta 143.4, 140.1, 138.0, 134.4, 131.8,128.2, 126.7, 126.2, 123.7. ICP-EOS: Recalcd: 34.33; Refound:34.39. Analysis calculated (%): C 28.79, H 1.49, S 5.91; found:C 28.19, H 1.42, S 5.82.

22913-24-2, As the paragraph descriping shows that 22913-24-2 is playing an increasingly important role.

Reference£º
Article; Nkoe, Pheello I.; Visser, Hendrik G.; Swart, Chantel; Brinka, Alice; Schutte-Smith, Marietjie; Acta Crystallographica Section C: Structural Chemistry; vol. 74; 10; (2018); p. 1116 – 1122;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, Benzo[b]thiophene-3-carbaldehyde (1.0 equiv.) in toluene (5 mL) was slowly added with constant stirring to a 50 mL three-necked round bottomf lask containing substituted 2-aminobenzothiazole (1.0 equiv.) and anhydrous toluene (10 mL). The reaction mixture was refluxed for 10 h and then cooled down to room temperature. The solvent was removed under reduced pressure, and the crude product was purified by recrystallization using N,N-dimethylethanamine/acetone/petroleum etherto yield pure imines 1a-1f.

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Peiwei; Tang, Chenghao; Chen, Zhiwei; Wang, Bo; Wang, Xiang; Jin, Linhong; Yang, Song; Hu, Deyu; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 189; 4; (2014); p. 530 – 540;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

360575-29-7, Methyl 4-bromobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

12151] A mixture of 750 ng of methyl 4-bromobenzo[b] thiophene-2-carboxylate, 438mg of phenyl boronic acid, 610 mg of lithium chloride, 528mg of sodium carbonate, 160mg of tetrakis(triphenylphosphine)palladium (0), 30 ml of 1,4- dioxane, and 15 ml of water was stirred for 4 hours at 1000 C. under nitrogen atmosphere. After being cooled to room temperature, the reaction mixture was concentrated under reduced pressure. Chloroform and water were added to the residues, and insoluble matter was separated by filtration. The aqueous layer was extracted twice by using chloroform, and the collected organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The residues were subjected to silica gel column chromatography, thereby obtaining 477mg of methyl 4-phenylbenzo[b]thiophene-2-carboxylate (hereinafier, described as a ?compound 34 of the present invention?).12152] Compound 34 of the Present Inventionj2153] ?H-NMR (CDC13) oe: 8.17-8.16 (m, 1H), 7.87-7.85 (m, 1H), 7.57-7.48 (m, 5H), 7.47-7.42 (m, 1H), 7.41-7.39 (m, 1H), 3.93 (s, 3H)., 360575-29-7

The synthetic route of 360575-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

95-15-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.

To 30 g (0.224 mol) of benzothiophene was added 500 mL of THF. After cooling to -78 C, 98.3 mL (0.246 mol) of n-BuLi 2.5M solution was slowly added dropwise. After stirring for 1 hour, 14.4 g (0.447 mol) of sulfur was added to the reaction solution. The temperature was slowly raised to room temperature, and the mixture was stirred for 12 hours and then 300 mL of 12N HCl aqueous solution was added to terminate the reaction. Separated and washed with distilled water and brine. The obtained organic layer was dried over anhydrous MgSO4, distilled under reduced pressure, and then purified by silica gel column chromatography to obtain the desired compound (25.3 g, yield 68%).

As the paragraph descriping shows that 95-15-8 is playing an increasingly important role.

Reference£º
Patent; Doosan Corporation; Sim, Jae Uii; Son, Hyo Suk; Lee, Jae Hun; Park, Ho Chul; Lee, Chang Jun; Sin, Jin Yong; Baek, Young Mi; (21 pag.)KR2015/27443; (2015); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

360576-01-8, Methyl 6-bromobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Lithium aluminum hydride (756 mg, 19.9 mmol)Was suspended in tetrahydrofuran (20.0 mL)And the mixture was stirred under ice cooling.Compound 8 (1.79 g, 6.64 mmol) synthesized by the method shown in Example 3-1 was dissolved in tetrahydrofuran (20.0 mL).The resulting solution of Compound 8 was added to a solutionThe solution was slowly added dropwise to a lithium aluminum hydride solution under ice cooling, followed by stirring at room temperature for 3 hours.Saturated sodium sulfate aqueous solution was added excessively,It was dehydrated with sodium sulfate powder.After filtration with a glass filter, the solvent was distilled off under reduced pressure,The residue was subjected to silica gel column chromatography using ethyl acetate / hexane (1/1, volume ratio) as an elution solvent,Compound 9 was obtained in a yield of 1.20 g (yield: 74.7%)., 360576-01-8

As the paragraph descriping shows that 360576-01-8 is playing an increasingly important role.

Reference£º
Patent; KYOTO UNIVERSITY; NIHON MEDI-PHYSICS COMPANY LIMITED; SAJI, HIDEO; ONO, MASAHIRO; IHARA, MASAFUMI; SEKI, IKUYA; (27 pag.)JP2015/89879; (2015); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.

5-Bromobenzothiophene (1.60 g, 7.51 mmol) and dichloromethyl methyl ether (1.29 g, 11.3 mmol) were dissolved in anhydrous 1,2-dichloroethane (75 mL). Titanium tetrachloride (2.14 g, 11.3 mmol) was added, turning the solution dark. After one hour at room temperature, the reaction was poured into a mixture of saturated aqueous NaHCO3 and ice. The mixture was stirred for about 30 minutes and then was extracted with DCM (2¡Á100 mL). The extracts were concentrated and chromatographed (0 to 5% ethyl acetate in hexane) to yield 5-bromo-benzo[b]thiophene-3-carbaldehyde (1.32 g). The 5-bromobenzothiophene-3-carboxaldehyde (1.20 g, 4.98 mmol) and sulfamide (4.0 g, 42 mmol) were combined in anhydrous ethanol (25 mL) and heated to reflux for three days. The reaction was cooled to room temperature and sodium borohydride (0.207 g, 5.47 mmol) was added. After five hours, water (50 ml) was added and the solution was extracted with chloroform (3¡Á50 mL). The extracts were concentrated, suspended in a minimal amount of DCM, and filtered to provide the title compound as a yellow solid.1H NMR (DMSO-d6): delta 8.12 (1H, d, J=1.8 Hz), 7.97 (1H, d, J=8.6), 7.71 (1H, s), 7.52 (1H, dd, J=8.6, 1.9 Hz), 7.12 (1H, t, J=6.3 Hz), 6.72 (2H, s), 4.28 (2H, d, J=6.2 Hz)., 4923-87-9

The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Smith-Swintosky, Virginia L.; US2007/191460; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, General procedure: As a typical experiment, the reaction of the aryl bromide (1 mmol), benzothiophene (1.5 mmol) and KOAc (0.196 g, 2 mmol) at 150C during 16 h in DMF or DMAc (4 mL) in the presence of Pd(OAc)2 (0.224 mg,0.001 mmol) or (1.12 mg, 0.005 mmol) prepared as a solution in DMAc (1 mg of Pd(OAc)2 in 1 mL of DMAc) under argon affords the coupling product after evaporation of the solvent and purificationon silica gel.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Zhao, Liqin; Bruneau, Christian; Doucet, Henri; Tetrahedron; vol. 69; 34; (2013); p. 7082 – 7089;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem