With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
Compound 60 (29 mg, 0.118 mmol) and compound 61 (37 mg, 0.177 mmol) were dissolved in DMF (1.18 mL). EDC (34 mg, 0.177 mmol) was added to the reaction mixture, followed by DMAP (14 mg, 0.118 mmol). The reaction was stirred at rt for 2 h. The solution was diluted with water and EtOAc and the layers were separated. The organic layer was washed with sat’d NH4Cl, water (3x), dried over Na2S04, filtered and concentrated. The crude residue was purified by RPHPLC (Cl 8 column, ACN/H20) to obtain compound 62 as a solid (10 mg, 0.023 mmol, 20% yield). UPLCMS = 1.69 min (2.5 min method). Mass observed (ESI+): 436.3 (M+H)., 20699-85-8
As the paragraph descriping shows that 20699-85-8 is playing an increasingly important role.
Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; CHARI, Ravi, V.J.; (312 pag.)WO2019/133652; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem