With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.
To a stirred solution of N-(phenylthio)-succinamide (20 mg, 0.10 mmol) in 3 mL of 3:1 methanol-HEPES buffer (50 mM HEPES, 100 mM NaCl and 1 mM EDTA) was added C (19 mg, 0.11 mmol) and the reaction stirred at 24 C for 4 h. The solid formed during the reaction was collected on a sintered glass funnel and washed with ice cold water (2 * 2 mL) to afford 7 as a white powder (17.5 mg, 91% yield) mp: 134-136 C Rf = 0.70 (30% ethyl acetate/hexanes). 1H NMR (CDCl3, 500 MHz) delta 7.95 (d, J = 7.5 Hz, 1H), delta 7.86-7.89 (m, 1H), delta 7.79 (d, J = 7.5 Hz, 1H), delta 7.71-7.74 (m, 1H), delta 7.65-7.67 (m, 4H), delta 7.38-7.42 (m, 2H), delta 7.38 (t, J = 7.5 Hz, 4H); 13C NMR (CDCl3, 125 MHz) delta 183.2, 142.8, 137.0, 136.7, 134.3, 131.0, 130.5, 128.9, 127.6, 125.4, 122.3, 82.9; IR (cm-1) 3056, 2982, 1724, 1328, 1270, 1160, 739, 702; HRMS (ESI-TOF, [M+H]+) m/z calcd for C20H15O3S3 399.0183, found 399.0169., 1127-35-1
As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.
Reference£º
Article; Parsons, Zachary D.; Ruddraraju, Kasi Viswanatharaju; Santo, Nicholas; Gates, Kent S.; Bioorganic and Medicinal Chemistry; vol. 24; 12; (2016); p. 2631 – 2640;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem