With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89673-36-9,tert-Butyl benzo[b]thiophen-2-ylcarbamate,as a common compound, the synthetic route is as follows.
89673-36-9, C. Benzo[b]thiophen-2-ylamine hydrochloride (1e). Compound 1d (1.45 g, 5.81 mmol) was added to a solution of HCl in dioxane (4 N, 20 mL). The mixture was stirred at room temperature until all the starting material was consumed. The mixture was diluted with diethyl ether, and the product was collected by filtration and washed with diethyl ether to give an off white solid (0.89 g, 83%). 1H NMR (DMSO-d6): delta 6.43 (s, 1H), 6.8-7.2 (br s, 3H) superimposed on 7.05 (m, 1H) and 7.20 (m, 1H), 7.45 (d, 1H) and 7.66 (d, 1H); MS: m/z 150.1 (MH+).
As the paragraph descriping shows that 89673-36-9 is playing an increasingly important role.
Reference£º
Patent; Macielag, Mark J.; McNally, James J.; US2010/160289; (2010); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem