With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22913-24-2,Methyl benzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
Methyl 4-chloromethyl-benzothiophene-2-carboxylate Refer to Chart A (conversion of XIII to XIV). A three-neck round-bottomed flask equipped with a magnetic stirring bar, a condenser, and a gas bubbler, is charged with a solution of methyl benzothiophene-2-carboxylate (XIII) (32.6 g, 0.17 mol) dissolved in 85 ml of chloroform. Paraformaldehyde (6.7 g, 0.22 mol) and zinc chloride (6.1 g, 0.045 mol) (dried at 100 C. under vacuum for 2 days) are addefd. The resulting mixture is heated to 50 C. and anhydrous hydrogen chloride gas is bubbled slowly through the magnetically stirred mixture. After 4-5 hr, the mixture is cooled, diluted with chloroform and washed with water, saturated aqueous sodium bicarbonate, and brine. Drying (MgSo4), filtration, and concentration afford the crude product which is purified by chromatography to give the titled product., 22913-24-2
As the paragraph descriping shows that 22913-24-2 is playing an increasingly important role.
Reference£º
Patent; The Upjohn Company; US4447620; (1984); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem