351005-12-4, 5-Bromo-1,3-dihydrobenzo[c]thiophene 2,2-dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
16. Preparation of 2-(2 ,2-dioxo-2,3-dihydro-1 H-benzo[c]thiophen-5-yl)-4,4,5,5- tetramethyl-[1 ,3,2]dioxaborolane In a screw-capped vessel 5-bromo-1 3-dihydro-benzo[c]thiophene2,2-dioxide (100 mg, 0.40 mmol), bis(pinacolato)diboron (206 mg,0.81 mmol), potassium acetate (119 mg, 1.21 mmol) and Pd(dppf)C12.CH2CI2 (33.1 mg, 0.04 mmol) were suspended in THE SeccoSolv (5 mL).Nitrogen was bubbled through the mixture for 5mm. The reaction mixture was stirred at70C for 15 h. The mixture was diluted with THF (7 mL), filtered and the filtrate wasevaporated to dryness. The crude residue was purified by flash chromatography(heptane/DCM) to yield in 89.0 mg (75 %) of the title compound as an off-white solid.LC/MS (Method B): Rt = 2.53 mm, (M+Na) 317., 351005-12-4
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Reference£º
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, Kai; STIEBER, Frank; CALDERINI, Michel; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; (127 pag.)WO2015/144290; (2015); A1;,
Benzothiophene – Wikipedia
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