With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.
A solution of commercially available 7-bromobenzo[b]thiophene (8.0 g, 37.5 mmol) in ether (50.0 mL) was cooled to -78 C was and treated dropwise with BuLi (1.6 M solution in Hexanes, 21 mL, 37.5 mmol) and stirred at -78 C for 20 min. The reaction mixture was treated with DMF (5.4 g, 67.4 mmol) and stirred at -78 C for 1 h. The reaction mixture was diluted with water and extracted with ether. The combined organic layer were washed with water, dried (MgSO4) filtered concentrated in vacuo and purified by chromatography (SiO2, EtOAc/Hexanes) to yield 5 as a colorless oil. 1H NMR (400 MHz, CDCl3) delta 10.25 (s, 1H), 8.12 (d, 1 H, J = 7.6 Hz), 7.90 (d, 1H, J = 7.2 Hz), 7.67 (d, 1H, J = 5.6 Hz), 7.59 (t, 1H, J = 7.6 Hz), 7.45 (d, 1H, J = 5.6 Hz)., 1423-61-6
The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Venkatraman, Srikanth; Velazquez, Francisco; Gavalas, Stephen; Wu, Wanli; Chen, Kevin X.; Nair, Anilkumar G.; Bennett, Frank; Huang, Yuhua; Pinto, Patrick; Jiang, Yueheng; Selyutin, Oleg; Vibulbhan, Bancha; Zeng, Qingbei; Lesburg, Charles; Duca, Jose; Huang, Hsueh-Cheng; Agrawal, Sony; Jiang, Chuan-Kui; Ferrari, Eric; Li, Cheng; Kozlowski, Joseph; Rosenblum, Stuart; Shih, Neng-Yang; Njoroge, F. George; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 2007 – 2017;,
Benzothiophene – Wikipedia
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