With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-03-0,Benzo[b]thiophen-3(2H)-one,as a common compound, the synthetic route is as follows.
A representative procedure for synthesis of thioaurones is as follows. To a solution of 150 nig (1.00 mmol) of 1-thiobenzofuranone and the required aldehyde (1 mmol) in 2 mL of methanol was added 2 mL of a 50% by weight solution of potassium hydroxide in methanol. This mixture was heated to 60 C in a CEM microwave reactor for 30 minutes. After cooling, the reaction was acidified with 1-N HC1 and partitioned between ethyl acetate and water. The organic layer was directly concentrated in vacuo and then purified via column chromatography on silica using ethyl acetate/hexanes mixtures to afford the desired thioaurone product as a solid in 20-50% yield. These products displayed spectroscopic data consistent with the assigned structure., 130-03-0
The synthetic route of 130-03-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MIDDLE TENNESSEE STATE UNIVERSITY; STUBBLEFIELD, Jeannie; TAYLOR, Zachary, E.; HANDY, Scott; FARONE, Mary; MCCLELLAND, Erin; SUTTON, Caleb; FARONE, Anthony; PARK, Hyo; ARAUJO, Danielle; (247 pag.)WO2017/180644; (2017); A1;,
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