With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
5381-20-4, General procedure: Amixture of the heterocyclic salt I1-I16 (2.5 mmol), aldehyde (7.5 mmol, 3 molar equiv, unlessotherwise stated) and piperidine (0.50 mL, 5 mmol, 2 molar equiv) in EtOH (25 mL) was heatedunder reflux for 2.5 h. After cooling to room temperature, the precipitated solid was collectedby filtration, washed with EtOH (2 ¡Á 5 mL) and Et2O (2 ¡Á 5 mL) and dried. The crude iodidesalt was either purified through a recrystallization from a suitable solvent (as indicated below)to give an analytically pure sample, or subjected to anion exchange to bromide or chloride, asdescribed below. Procedure for anion exchange: Ion-exchange resin (Amberlite IRA-402, Cl- form, or AmberliteIRA-400, Br- form, about 20 mmol equiv) was thoroughly rinsed with a mixture of MeCN andMeOH (1:1, v/v) and charged into a short glass column. The dye (iodide salt) was dissolvedin a minimal amount of a mixture of MeCN and MeOH (1:1, v/v) and loaded in the column. Theproduct was then eluted with the same solvent mixture (about 50 mL). The solvents wereremoved in vacuo and the residue was recrystallized from a suitable solvent (as indicatedbelow), to give an analytically pure dye.
The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Xie, Xiao; Zuffo, Michela; Teulade-Fichou, Marie-Paule; Granzhan, Anton; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 1872 – 1889;,
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