With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17402-83-4,Benzo[b]thiophen-4-amine,as a common compound, the synthetic route is as follows.
l-Benzothiophen-4-amine (3.3g, 0.022 mol) was added to a stirred solution of ((4-((2-oxo-l,2- dihydroquinolin-7-yl)oxy)butyl)azanediyl)bis(ethane-2,l-diyl)dimethanesulfonate (10 g, 0.021 mol) in toluene (90 ml) at 25-35¡ãC. Then potassium tertiary butoxide (7.1g, 0.063 mol) was added to the reaction mixture slowly. Completion of reaction was confirmed using thin layer chromatography (TLC). After completion of the reaction, water (50 ml) was added to reaction mixture and extracted. The organic phase was separated and evaporated under vacuum to obtain residue. Methanol (50 ml) was added to the residue and stirred for 2 h at 25-35¡ãC. The solid obtained was filtered, washed with methanol (20 ml) then dried to obtain the title product as off white solid (10 g)., 17402-83-4
As the paragraph descriping shows that 17402-83-4 is playing an increasingly important role.
Reference£º
Patent; AMNEAL PHARMACEUTICALS COMPANY GMBH; JAGTAP, Bhushan Nimba; BADGUJAR, Narendra Dattatray; MAHETA, Abhay Subodhbhai; BUTANI, Pankaj Chhaganbhai; AJUDIA, Paragkumar Vrujlal; KOILPILLAI, Joseph Prabahar; AGARWAL, Virendra Kumar; HEDAPARA, Kalpesh Ratilal; (96 pag.)WO2018/172463; (2018); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem