1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Scheme I, step C: To magnesium turnings (703 mg, 0.0289 mole) in 10 mL anhydrous tetrahydrofuran was added part of a solution of of 7-bromobenzothiophene (6.16 g, 0.0289 mole) in 30 mL anhydrous tetrahydrofuran. The mixture was brought to reflux and when the grignard reaction started, foaming was controlled by removing the heating mantle. The balance of the benzothiophene solution was added at a rate to maintain gentle reflux and then refluxed an additional hour. The reaction was cooled to 25 C. and of N-boc-3-pyrrolidone (5.34 g, 0.0289 mole) in 20 mL anhydrous tetrahydrofuran was added. The reaction was refluxed 1 hr and then stirred at room temperature overnight. The reaction was cooled in an ice bath and add dropwise saturated ammonium chloride solution until a granular precipitate was formed. The precipitate was filtered and rinsed with additional tetrahydrofuran. Evaporation gave 9.9 g of crude material as an oil which was flashed chromatographed over silica gel. Elution with 20% ethyl acetate in hexane provided the title compound (1.004 g, 11%) as a white foam. Mass Spec ESI+, M+1=320.2 (MW=319.4) 1H NMR (300 MHz, CDCl3) delta 1.48 (9H, s); 2.17 to 2.23 (3H, m); 3.71 to 3.94 (4H, m); 7.33 to 7.81 (5H, m).
1423-61-6, As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.
Reference£º
Patent; Eli Lilly and Company; US6353008; (2002); B1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem