4923-87-9,4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step A: To a solution of isoquinoline-4-boronic acid (378 mg, 2.013 mmol) and 5-bromobenzothiophene (286 mg, 1.342 mmol) in dichloroethane (8 mL), sodium carbonate (2 M aqueous, 2 mL, 4 mmol) was added and the solution degassed by alternately evacuating and releasing to argon three times. To this heterogenic mixture was added palladium tetrakistriphenylphosphine (76 mg, 0.6711 mmol), the reaction mixture was degassed 3 times and heated to 90 C. with agitation for 12 hours. To this mixture was added EtOAc (100 mL), the mixture washed with water (3¡Á100 mL), and dried over anhydrous sodium sulfate. Purification by column chromatography (SiO2, 30 g, 50% ethyl acetate/hexane) provided the product as a white solid (316 mg): 1H NMR (CDCl3, 300 MHz) delta 9.29 (s, 1H), 8.55 (s, 1H), 8.06-7.97 (m, 4H), 7.68-7.65 (m, 2H), 7.56-7.42 (m, 3H). ESI-MS calc. for C17H11NS [M+H]+ 262. Found 262.
As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.
Reference£º
Patent; Molino, Bruce F.; Liu, Shuang; Guzzo, Peter R.; Beck, James P.; US2006/52378; (2006); A1;,
Benzothiophene – Wikipedia
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