34761-09-6, Ethyl 3-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of ethyl 3-amino-benzo[b]thiophene-2-carboxylate (8) (0.50 g, 2.3 mmol) in acetic acid (6 mL), was cooled in an ice bath to -5 C. Then, a solution of sodium nitrite (0.32 g, 4.6 mmol), in water (2 mL), was slowly added, under vigorous stirring. After 30 min, sodium azide (0.60 g, 9.2 mmol) in water (2 mL), was added over 10 min. The reaction mixture was stirred for further 3 h at room temperature and then slowly poured onto water/ice. The precipitate was collected by filtration to give 5, 0.40 g. Yield 70%. Mp 100 C (dec). IR: 2130 (N3), 1689 (CO) cm-1. 1H NMR delta: 1.30 (t, J = 7.1 Hz, 3H), 4.33 (q, J = 7.1 Hz, 2H), 7.34-7.51 (m, 2H), 7.88 (d, J = 8.1 Hz, 1H), 8.14 (d, J = 7.7 Hz, 1H). 13C NMR delta: 14.4 (q), 59.7 (t), 122.9 (d), 123.0 (d), 123.8 (d), 128.4 (d), 131.5 (s), 133.7 (s), 138.8 (s), 149.7 (s), 164.5 (s). Elem. Anal. calcd. for C11H9N3O2S: C, 53.43; H, 3.67; N, 16.99; found: C, 53.62; H, 3.55; N, 17.30.
34761-09-6, 34761-09-6 Ethyl 3-aminobenzo[b]thiophene-2-carboxylate 731510, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Article; Lauria, Antonino; Abbate, Ilenia; Patella, Chiara; Martorana, Annamaria; Dattolo, Gaetano; Almerico, Anna Maria; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 416 – 424;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem